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• W2783175774 abstract "Over the past two decades, hundreds of new somatic mutations have been identified in tumours, and a few dozen novel cancer therapeutics that selectively target these mutated oncoproteins have entered clinical practice. This development has resulted in clinical breakthroughs for a few tumour types, but more commonly patients' overall survival has not improved because of the development of drug resistance. Furthermore, only a very limited number of oncoproteins, largely protein kinases, are successfully targeted, whereas most non-kinase oncoproteins inside cancer cells remain untargeted. Engineered small protein inhibitors offer great promise in targeting a larger variety of oncoproteins with better efficacy and higher selectivity. In this article, I focus on a promising class of synthetic binding proteins, termed monobodies, that we have shown to inhibit previously untargetable protein-protein interactions in different oncoproteins. I will discuss the great promise alongside the technical challenges inherent in converting monobodies from potent pre-clinical target validation tools to next-generation protein-based therapeutics." @default.
• W2783175774 created "2018-01-26" @default.
• W2783175774 date "2017-11-20" @default.
• W2783175774 modified "2023-09-25" @default.
• W2783175774 title "Monobodies as possible next-generation protein therapeutics – a perspective" @default.
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• W2783175774 doi "https://doi.org/10.4414/smw.2017.14545" @default.
• W2783175774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7316567" @default.
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• W2783175774 hasPublicationYear "2017" @default.
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