Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783176980> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2783176980 endingPage "120.11" @default.
- W2783176980 startingPage "120.11" @default.
- W2783176980 abstract "Abstract Eosinophilia is one of the characteristic signs of allergic inflammation. Previously, we discovered a new compound, PPY, derived from the fruit of Vitex rotundifolia L. and evaluated its anti-inflammatory and anti-asthmatic properties. In this study, we synthesized a new modified compound, PPY-345, which was based on the PPY skeleton, and we evaluated its anti-asthmatic effects. To evaluate the anti-asthmatic effect of PPY-345 in vitro, A549 lung epithelial cells were stimulated with TNF-alpha, IL-4 and IL-1-beta to induce the expression of CCL11, a chemokine involved in eosinophil chemotaxis. PPY-345 treatments significantly reduced CCL11 secretion. PPY-345 treatment did not inhibit the translocation of NF-κB into the nucleus but suppressed the phosphorylation of signal transducers and activators of transcription 6. To characterize the anti-asthmatic properties of PPY-345 in vivo, we examined the influence of PPY-345 in an ovalbumin (OVA)-induced asthma model. PPY-345 treatment significantly reduced airway hyperreactivity as measured by whole-body plethysmography. PPY-345 further reduced total cells, including eosinophil, macrophage and lymphocytes, in the BAL fluid, goblet cell hyperplasia and myosin light chain 2 positive smooth muscle cell area in the lung tissue. Additionally, PPY-345 significantly suppressed the levels of OVA-IgE present in the serum. These results suggested that PPY-345 could improve asthma symptoms in OVA-sensitized mice." @default.
- W2783176980 created "2018-01-26" @default.
- W2783176980 creator A5040469592 @default.
- W2783176980 creator A5040649127 @default.
- W2783176980 creator A5054619950 @default.
- W2783176980 creator A5054646845 @default.
- W2783176980 creator A5056367866 @default.
- W2783176980 creator A5057411051 @default.
- W2783176980 creator A5062074486 @default.
- W2783176980 creator A5067408278 @default.
- W2783176980 creator A5080823003 @default.
- W2783176980 date "2013-05-01" @default.
- W2783176980 modified "2023-09-26" @default.
- W2783176980 title "A synthetic compound, PPY-345, ameliorates ovalbumin-induced asthma (P6021)" @default.
- W2783176980 doi "https://doi.org/10.4049/jimmunol.190.supp.120.11" @default.
- W2783176980 hasPublicationYear "2013" @default.
- W2783176980 type Work @default.
- W2783176980 sameAs 2783176980 @default.
- W2783176980 citedByCount "0" @default.
- W2783176980 crossrefType "journal-article" @default.
- W2783176980 hasAuthorship W2783176980A5040469592 @default.
- W2783176980 hasAuthorship W2783176980A5040649127 @default.
- W2783176980 hasAuthorship W2783176980A5054619950 @default.
- W2783176980 hasAuthorship W2783176980A5054646845 @default.
- W2783176980 hasAuthorship W2783176980A5056367866 @default.
- W2783176980 hasAuthorship W2783176980A5057411051 @default.
- W2783176980 hasAuthorship W2783176980A5062074486 @default.
- W2783176980 hasAuthorship W2783176980A5067408278 @default.
- W2783176980 hasAuthorship W2783176980A5080823003 @default.
- W2783176980 hasConcept C13373296 @default.
- W2783176980 hasConcept C141105273 @default.
- W2783176980 hasConcept C150903083 @default.
- W2783176980 hasConcept C159654299 @default.
- W2783176980 hasConcept C185592680 @default.
- W2783176980 hasConcept C203014093 @default.
- W2783176980 hasConcept C207001950 @default.
- W2783176980 hasConcept C2776042228 @default.
- W2783176980 hasConcept C2776914184 @default.
- W2783176980 hasConcept C2776946954 @default.
- W2783176980 hasConcept C2777037409 @default.
- W2783176980 hasConcept C2777129736 @default.
- W2783176980 hasConcept C2777716647 @default.
- W2783176980 hasConcept C2780590879 @default.
- W2783176980 hasConcept C71924100 @default.
- W2783176980 hasConcept C86803240 @default.
- W2783176980 hasConcept C8891405 @default.
- W2783176980 hasConceptScore W2783176980C13373296 @default.
- W2783176980 hasConceptScore W2783176980C141105273 @default.
- W2783176980 hasConceptScore W2783176980C150903083 @default.
- W2783176980 hasConceptScore W2783176980C159654299 @default.
- W2783176980 hasConceptScore W2783176980C185592680 @default.
- W2783176980 hasConceptScore W2783176980C203014093 @default.
- W2783176980 hasConceptScore W2783176980C207001950 @default.
- W2783176980 hasConceptScore W2783176980C2776042228 @default.
- W2783176980 hasConceptScore W2783176980C2776914184 @default.
- W2783176980 hasConceptScore W2783176980C2776946954 @default.
- W2783176980 hasConceptScore W2783176980C2777037409 @default.
- W2783176980 hasConceptScore W2783176980C2777129736 @default.
- W2783176980 hasConceptScore W2783176980C2777716647 @default.
- W2783176980 hasConceptScore W2783176980C2780590879 @default.
- W2783176980 hasConceptScore W2783176980C71924100 @default.
- W2783176980 hasConceptScore W2783176980C86803240 @default.
- W2783176980 hasConceptScore W2783176980C8891405 @default.
- W2783176980 hasIssue "1_Supplement" @default.
- W2783176980 hasLocation W27831769801 @default.
- W2783176980 hasOpenAccess W2783176980 @default.
- W2783176980 hasPrimaryLocation W27831769801 @default.
- W2783176980 hasRelatedWork W1854728040 @default.
- W2783176980 hasRelatedWork W1999705022 @default.
- W2783176980 hasRelatedWork W2003499486 @default.
- W2783176980 hasRelatedWork W2089221375 @default.
- W2783176980 hasRelatedWork W2104449005 @default.
- W2783176980 hasRelatedWork W2114256314 @default.
- W2783176980 hasRelatedWork W2122445545 @default.
- W2783176980 hasRelatedWork W2133656592 @default.
- W2783176980 hasRelatedWork W2166189303 @default.
- W2783176980 hasRelatedWork W2567437557 @default.
- W2783176980 hasVolume "190" @default.
- W2783176980 isParatext "false" @default.
- W2783176980 isRetracted "false" @default.
- W2783176980 magId "2783176980" @default.
- W2783176980 workType "article" @default.