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- W2783177615 abstract "The influence of 2-(2-nitrovinyl) furan on the activities of selected bacteriostatic and bactericidal antibiotics was investigated. Minimum inhibitory concentration and fractional inhibitory concentration index were determined to evaluate the interaction between 2-(2-nitrovinyl) furan and the antibiotics. 2-(2-nitrovinyl) furan exhibited additive interactions with chloramphenicol, erythromycin, lincomycin and gemifloxacin. However, synergistic interaction was observed with amoxicillin, ampicillin and ciprofloxacin. Superoxide anion content of Escherichia coli exposed to antibiotics with/without 2-(2-nitrovinyl) furan increased significantly (p < .05). Furthermore, reduced glutathione decreased significantly with a corresponding increase in glutathione disulphide. In addition, malondialdehyde, a product of lipid peroxidation, increased significantly in E. coli exposed to antibiotics and 2-(2-nitrovinyl) furan. It can be deduced from this study that 2-(2-nitrovinyl) furan enhanced bacteriostatic and bactericidal antibiotics-mediated bacterial death possibly by potentiating reactive oxygen species generation and oxidative stress." @default.
- W2783177615 created "2018-01-26" @default.
- W2783177615 creator A5069155923 @default.
- W2783177615 date "2018-03-01" @default.
- W2783177615 modified "2023-09-27" @default.
- W2783177615 title "2-(2-Nitrovinyl) furan exacerbates oxidative stress response of Escherichia coli to bacteriostatic and bactericidal antibiotics" @default.
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- W2783177615 doi "https://doi.org/10.1016/j.micpath.2018.01.010" @default.
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