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- W2783179873 abstract "Abstract Aim Cyclosporine A (CsA) induces renal vasoconstriction and hypoxia and enhances the expression of endothelin‐1 ( ET ‐1) pro‐hormone (pre‐pro‐ ET ‐1), plausibly leading to a feed‐forward loop of renal vasoconstriction, hypoxia and enhanced synthesis of the potent vasoconstrictor ET ‐1. Endothelin‐converting enzyme ( ECE )‐1 cleaves big endothelin to generate endothelin ( ET )‐1 and is upregulated by hypoxia via hypoxia‐inducible factor ( HIF ). We hypothesized that in addition to the direct induction of ET ‐1 synthesis, CsA might also intensify renal ECE ‐1 expression, thus contributing to enhanced ET ‐1 synthesis following CsA. Methods CsA was administered to Sprague Dawley rats (120 mg/kg/ SC ) for 4 days, and renal HIF and ECE ‐1 expression were assessed with Western blots and immunostaining. Human umbilical vein endothelial cells ( HUVEC ) and proximal tubular cell line ( HK ‐2) were subjected to CsA, and ECE ‐1 induction was evaluated using real‐time mRNA PCR and Western blots. Results Cyclosporine A intensified renal parenchymal ECE ‐1 expression in the rat kidney, particularly in distal nephron segments, along with renal hypoxia (detected by pimonidazole adducts) and HIF expression, in line with our recent observations showing episodic hypoxia in mice subjected to CsA. Furthermore, in cultured normoxic HUVEC and HK ‐2 cells, CsA dose‐dependently induced both pre‐pro‐ ET ‐1 and ECE ‐1 mRNA and protein expression, with enhanced ET ‐1 generation. Conclusion CsA induces ECE ‐1 via both hypoxic and non‐hypoxic pathways. ECE ‐1 may contribute to increased renal ET ‐1 generation following CsA, participating in a feed‐forward loop of renal parenchymal hypoxia and ET synthesis." @default.
- W2783179873 created "2018-01-26" @default.
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- W2783179873 date "2018-02-12" @default.
- W2783179873 modified "2023-10-02" @default.
- W2783179873 title "Cyclosporine A induces endothelin-converting enzyme-1: Studies in vivo and in vitro" @default.
- W2783179873 cites W1964290500 @default.
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- W2783179873 cites W1972305275 @default.
- W2783179873 cites W1974471327 @default.
- W2783179873 cites W1975366846 @default.
- W2783179873 cites W1978644580 @default.
- W2783179873 cites W1982628508 @default.
- W2783179873 cites W1983661554 @default.
- W2783179873 cites W1983758790 @default.
- W2783179873 cites W1984762252 @default.
- W2783179873 cites W1985971838 @default.
- W2783179873 cites W1986515922 @default.
- W2783179873 cites W1988838635 @default.
- W2783179873 cites W1989222325 @default.
- W2783179873 cites W1991874811 @default.
- W2783179873 cites W1998289175 @default.
- W2783179873 cites W2014623760 @default.
- W2783179873 cites W2039644249 @default.
- W2783179873 cites W2040295042 @default.
- W2783179873 cites W2044527055 @default.
- W2783179873 cites W2046221239 @default.
- W2783179873 cites W2047111978 @default.
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- W2783179873 doi "https://doi.org/10.1111/apha.13033" @default.
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