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- W2783180367 endingPage "192" @default.
- W2783180367 startingPage "178" @default.
- W2783180367 abstract "Migration of dendritic cells (DC) to the central nervous system (CNS) is a critical event in the pathogenesis of multiple sclerosis (MS). While up until now, research has mainly focused on the transmigration of DC through the blood-brain barrier, experimental evidence points out that also the choroid plexus and meningeal vessels represent important gateways to the CNS, especially in early disease stages. On the other hand, DC can exit the CNS to maintain immunological tolerance to patterns expressed in the CNS, a process that is perturbed in MS. Targeting trafficking of immune cells, including DC, to the CNS has demonstrated to be a successful strategy to treat MS. However, this approach is known to compromise protective immune surveillance of the brain. Unravelling the migratory paths of regulatory and pathogenic DC within the CNS may ultimately lead to the design of new therapeutic strategies able to selectively interfere with the recruitment of pathogenic DC to the CNS, while leaving host protective mechanisms intact." @default.
- W2783180367 created "2018-01-26" @default.
- W2783180367 creator A5049815815 @default.
- W2783180367 creator A5063597549 @default.
- W2783180367 creator A5086410678 @default.
- W2783180367 date "2018-01-12" @default.
- W2783180367 modified "2023-10-10" @default.
- W2783180367 title "To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis" @default.
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