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• W2783184179 abstract "Pyrazole analogs of the staurosporine aglycon K252c were recently described as potent inhibitors of the three Pim protein kinase isoforms. To evaluate the impact of the introduction of a sugar moiety on the biological activities of this heterocyclic scaffold, four new glucosylated pyrazole analogs of K252c were synthesized. Their biological evaluation demonstrated that most active compounds 11 and 19 substituted by a β-d-glucosyl moiety at N12 or N13 positions exhibited antiproliferative activities toward HCT116 cells." @default.
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• W2783184179 date "2018-02-01" @default.
• W2783184179 modified "2023-10-05" @default.
• W2783184179 title "Synthesis and antiproliferative evaluation of glucosylated pyrazole analogs of K252c" @default.
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• W2783184179 doi "https://doi.org/10.1016/j.tet.2018.01.017" @default.
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