Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783185054> ?p ?o ?g. }
- W2783185054 endingPage "107" @default.
- W2783185054 startingPage "93" @default.
- W2783185054 abstract "A series of neuroprotective hybrid compounds was synthesized by conjugation of the flavonolignan silibinin with natural phenolic acids, such as ferulic, cinnamic and syringic acid. Selective 7-O-esterfication without protection groups was achieved by applying the respective acyl chlorides. Sixteen compounds were obtained and SARs were established by evaluating antioxidative properties in the physicochemical FRAP assay, as well as in a cell-based neuroprotection assay using murine hippocampal HT-22 cells. Despite weak activities in the FRAP assay, esters of the α,β-unsaturated acids showed pronounced overadditive effects at low concentrations greatly exceeding the effects of equimolar mixtures of silibinin and the respective acids in the neuroprotection assay. Cinnamic and ferulic acid esters (5a and 6a) also showed overadditive effects regarding inhibition of microglial activation, PC12 cell differentiation, in vitro ischemia as well as anti-aggregating abilities against Aβ42 peptide and τ protein. Remarkably, the esters of ferulic acid with silybin A and silybin B (11a and 11b) showed a moderate but significant difference in both neuroprotection and in their anti-aggregating capacities. The results demonstrate that non-toxic natural antioxidants can be regioselectively connected as esters with medium-term stability exhibiting very pronounced overadditive effects in a portfolio of biological assays." @default.
- W2783185054 created "2018-01-26" @default.
- W2783185054 creator A5003758032 @default.
- W2783185054 creator A5012588252 @default.
- W2783185054 creator A5013055662 @default.
- W2783185054 creator A5040653638 @default.
- W2783185054 creator A5043223203 @default.
- W2783185054 creator A5051025265 @default.
- W2783185054 creator A5063949825 @default.
- W2783185054 creator A5077599061 @default.
- W2783185054 creator A5084208566 @default.
- W2783185054 date "2018-02-01" @default.
- W2783185054 modified "2023-10-15" @default.
- W2783185054 title "Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects" @default.
- W2783185054 cites W1523091045 @default.
- W2783185054 cites W1966531138 @default.
- W2783185054 cites W1966684320 @default.
- W2783185054 cites W1977656346 @default.
- W2783185054 cites W1981142493 @default.
- W2783185054 cites W1981796480 @default.
- W2783185054 cites W1996946131 @default.
- W2783185054 cites W1998453665 @default.
- W2783185054 cites W2001544743 @default.
- W2783185054 cites W2006656242 @default.
- W2783185054 cites W2012446252 @default.
- W2783185054 cites W2014510311 @default.
- W2783185054 cites W2019750828 @default.
- W2783185054 cites W2021317119 @default.
- W2783185054 cites W2026456384 @default.
- W2783185054 cites W2027302343 @default.
- W2783185054 cites W2035895733 @default.
- W2783185054 cites W2037380525 @default.
- W2783185054 cites W2039335048 @default.
- W2783185054 cites W2039475633 @default.
- W2783185054 cites W2040675845 @default.
- W2783185054 cites W2043055154 @default.
- W2783185054 cites W2047269436 @default.
- W2783185054 cites W2050746675 @default.
- W2783185054 cites W2051344987 @default.
- W2783185054 cites W2055562863 @default.
- W2783185054 cites W2062124189 @default.
- W2783185054 cites W2062159889 @default.
- W2783185054 cites W2066921646 @default.
- W2783185054 cites W2068293210 @default.
- W2783185054 cites W2073676006 @default.
- W2783185054 cites W2077027511 @default.
- W2783185054 cites W2077064004 @default.
- W2783185054 cites W2094258059 @default.
- W2783185054 cites W2095284045 @default.
- W2783185054 cites W2104562968 @default.
- W2783185054 cites W2107376426 @default.
- W2783185054 cites W2133971230 @default.
- W2783185054 cites W2165292984 @default.
- W2783185054 cites W2171836350 @default.
- W2783185054 cites W2171864779 @default.
- W2783185054 cites W2302829883 @default.
- W2783185054 cites W2321717193 @default.
- W2783185054 cites W2327569274 @default.
- W2783185054 cites W2561828885 @default.
- W2783185054 cites W2567103081 @default.
- W2783185054 cites W2580247531 @default.
- W2783185054 cites W2612091984 @default.
- W2783185054 cites W2619614676 @default.
- W2783185054 cites W3023013291 @default.
- W2783185054 doi "https://doi.org/10.1016/j.ejmech.2018.01.036" @default.
- W2783185054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29407994" @default.
- W2783185054 hasPublicationYear "2018" @default.
- W2783185054 type Work @default.
- W2783185054 sameAs 2783185054 @default.
- W2783185054 citedByCount "18" @default.
- W2783185054 countsByYear W27831850542018 @default.
- W2783185054 countsByYear W27831850542019 @default.
- W2783185054 countsByYear W27831850542020 @default.
- W2783185054 countsByYear W27831850542021 @default.
- W2783185054 countsByYear W27831850542022 @default.
- W2783185054 countsByYear W27831850542023 @default.
- W2783185054 crossrefType "journal-article" @default.
- W2783185054 hasAuthorship W2783185054A5003758032 @default.
- W2783185054 hasAuthorship W2783185054A5012588252 @default.
- W2783185054 hasAuthorship W2783185054A5013055662 @default.
- W2783185054 hasAuthorship W2783185054A5040653638 @default.
- W2783185054 hasAuthorship W2783185054A5043223203 @default.
- W2783185054 hasAuthorship W2783185054A5051025265 @default.
- W2783185054 hasAuthorship W2783185054A5063949825 @default.
- W2783185054 hasAuthorship W2783185054A5077599061 @default.
- W2783185054 hasAuthorship W2783185054A5084208566 @default.
- W2783185054 hasConcept C185592680 @default.
- W2783185054 hasConcept C25498285 @default.
- W2783185054 hasConcept C2777130413 @default.
- W2783185054 hasConcept C2778831176 @default.
- W2783185054 hasConcept C2780213334 @default.
- W2783185054 hasConcept C55493867 @default.
- W2783185054 hasConcept C71924100 @default.
- W2783185054 hasConcept C98274493 @default.
- W2783185054 hasConceptScore W2783185054C185592680 @default.
- W2783185054 hasConceptScore W2783185054C25498285 @default.
- W2783185054 hasConceptScore W2783185054C2777130413 @default.
- W2783185054 hasConceptScore W2783185054C2778831176 @default.