FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783188631> ?p ?o ?g. }

• W2783188631 endingPage "106" @default.
• W2783188631 startingPage "94" @default.
• W2783188631 abstract "Executive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to young adults or healthy controls, especially when associated with relatively preserved performance. Here we test the hypothesis of an alternative form of compensation, between different neuromodulator systems. 135 patients with Parkinson's Disease (PD) completed vesicular monoamine transporter type2 (VMAT2) and acetylcholinesterase PET scanning to assess the integrity of nigrostriatal dopaminergic, thalamic cholinergic, and cortical cholinergic pathways, and a behavioral test (Stroop + task-switching) that puts high demands on conflict processing, an important aspect of executive control. Supporting the compensatory hypothesis, regression models controlling for age and other covariates revealed an interaction between caudate dopamine and cortical cholinergic integrity: Cortical cholinergic integrity was a stronger predictor of conflict processing in patients with relatively low caudate dopaminergic function. These results suggest that although frontostriatal dopaminergic function plays a central role in executive control, cholinergic systems may also make an important contribution. The present results suggest potential pathways for remediation, and that the appropriate interventions for each patient may depend on their particular profile of decline. Furthermore, they help to elucidate the brain systems that underlie executive control, which may be important for understanding other disorders as well as executive function in healthy adults." @default.
• W2783188631 created "2018-01-26" @default.
• W2783188631 creator A5005694718 @default.
• W2783188631 creator A5014562669 @default.
• W2783188631 creator A5024462650 @default.
• W2783188631 creator A5068115190 @default.
• W2783188631 date "2019-04-01" @default.
• W2783188631 modified "2023-10-18" @default.
• W2783188631 title "Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease" @default.
• W2783188631 cites W1506736245 @default.
• W2783188631 cites W1715619412 @default.
• W2783188631 cites W1942921912 @default.
• W2783188631 cites W1966684691 @default.
• W2783188631 cites W1969210233 @default.
• W2783188631 cites W1973427834 @default.
• W2783188631 cites W1974277236 @default.
• W2783188631 cites W1975118796 @default.
• W2783188631 cites W1976825990 @default.
• W2783188631 cites W1978319605 @default.
• W2783188631 cites W1979984474 @default.
• W2783188631 cites W1980142446 @default.
• W2783188631 cites W1980281322 @default.
• W2783188631 cites W1981488967 @default.
• W2783188631 cites W1983103814 @default.
• W2783188631 cites W1988786589 @default.
• W2783188631 cites W1992851323 @default.
• W2783188631 cites W1994817905 @default.
• W2783188631 cites W1997230335 @default.
• W2783188631 cites W1999702935 @default.
• W2783188631 cites W2009021103 @default.
• W2783188631 cites W2011717274 @default.
• W2783188631 cites W2012437345 @default.
• W2783188631 cites W2016100003 @default.
• W2783188631 cites W2022637667 @default.
• W2783188631 cites W2022838908 @default.
• W2783188631 cites W2031427673 @default.
• W2783188631 cites W2039083311 @default.
• W2783188631 cites W2042808523 @default.
• W2783188631 cites W2046230471 @default.
• W2783188631 cites W2048755200 @default.
• W2783188631 cites W2052373532 @default.
• W2783188631 cites W2053096735 @default.
• W2783188631 cites W2057679038 @default.
• W2783188631 cites W2059498859 @default.
• W2783188631 cites W2064247269 @default.
• W2783188631 cites W2064963539 @default.
• W2783188631 cites W2064996887 @default.
• W2783188631 cites W2067495470 @default.
• W2783188631 cites W2067590452 @default.
• W2783188631 cites W2069127747 @default.
• W2783188631 cites W2071882565 @default.
• W2783188631 cites W2073093666 @default.
• W2783188631 cites W2079490962 @default.
• W2783188631 cites W2080285028 @default.
• W2783188631 cites W2087484885 @default.
• W2783188631 cites W2087485448 @default.
• W2783188631 cites W2087598124 @default.
• W2783188631 cites W2089085990 @default.
• W2783188631 cites W2093330582 @default.
• W2783188631 cites W2093785622 @default.
• W2783188631 cites W2094992908 @default.
• W2783188631 cites W2095882961 @default.
• W2783188631 cites W2097145605 @default.
• W2783188631 cites W2101049573 @default.
• W2783188631 cites W2101491694 @default.
• W2783188631 cites W2104434501 @default.
• W2783188631 cites W2106430881 @default.
• W2783188631 cites W2107147983 @default.
• W2783188631 cites W2117800611 @default.
• W2783188631 cites W2117971276 @default.
• W2783188631 cites W2118298714 @default.
• W2783188631 cites W2118932991 @default.
• W2783188631 cites W2121145464 @default.
• W2783188631 cites W2124517301 @default.
• W2783188631 cites W2129478155 @default.
• W2783188631 cites W2130678362 @default.
• W2783188631 cites W2131168315 @default.
• W2783188631 cites W2132363607 @default.
• W2783188631 cites W2136276716 @default.
• W2783188631 cites W2137599726 @default.
• W2783188631 cites W2143200987 @default.
• W2783188631 cites W2147988018 @default.
• W2783188631 cites W2149431833 @default.
• W2783188631 cites W2149451815 @default.
• W2783188631 cites W2155694557 @default.
• W2783188631 cites W2158513338 @default.
• W2783188631 cites W2165731124 @default.
• W2783188631 cites W2165758561 @default.
• W2783188631 cites W2167792419 @default.
• W2783188631 cites W2172024882 @default.
• W2783188631 cites W2228895198 @default.
• W2783188631 cites W2253687122 @default.
• W2783188631 cites W2283703766 @default.
• W2783188631 cites W2283880077 @default.
• W2783188631 cites W2410446460 @default.
• W2783188631 cites W2503470823 @default.
• W2783188631 cites W2508027063 @default.
• W2783188631 cites W2546495434 @default.

• next