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- W2783191852 abstract "Early detection of pathogens or their virulence factors in complex media has a key role in early diagnosis and treatment of many diseases. Nanomolar and selective detection of Exotoxin A, which is a virulence factor secreted from Pseudomonas aeruginosa in the sputum of Cystic Fibrosis (CF) patients, can pave the way for early diagnosis of P. aeruginosa infections. In this study, we conducted a preliminary study to demonstrate the feasibility of optical biodetection of P. aeruginosa Exotoxin A in a diluted artificial sputum mimicking the CF respiratory environment. Our surface engineering approach provides an effective biointerface enabling highly selective detection of the Exotoxin A molecules in the complex media using monoclonal anti-Exotoxin A functionalized microtoroids. The highly resilient microtoroid surface toward other constituents of the sputum provides Exotoxin A detection ability in the complex media by reproducible measurements. In this study, the limit-of-detection of Exotoxin A in the complex media is calculated as 2.45 nM." @default.
- W2783191852 created "2018-01-26" @default.
- W2783191852 creator A5018991969 @default.
- W2783191852 creator A5028224275 @default.
- W2783191852 creator A5079058057 @default.
- W2783191852 date "2018-01-30" @default.
- W2783191852 modified "2023-10-17" @default.
- W2783191852 title "Label-Free Optical Biodetection of Pathogen Virulence Factors in Complex Media Using Microtoroids with Multifunctional Surface Functionality" @default.
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- W2783191852 doi "https://doi.org/10.1021/acssensors.7b00775" @default.
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- W2783191852 hasPublicationYear "2018" @default.
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