FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783192036> ?p ?o ?g. }

• W2783192036 abstract "Background:Dendrobium officinale, a traditional Chinese medical herb with high value that is widely used in Asia, possesses many positive effects on human health, including anti-chronic inflammation, anti-obesity, and immune modulation properties; however, whether D. officinale has inhibitory effects on postmenopausal osteoporosis remains unknown. Objective: We investigated the effects of D. officinale extract (DOE) on ovariectomy-induced bone loss in vivo and on osteoclastogenesis in vitro. Methods:In vivo, female rats were divided into a sham-operated (sham) group and five ovariectomized (OVX) subgroups: OVX with vehicle (OVX), OVX with Xian-Ling-Gu-Bao capsule (240 mg/kg body weight/day), and OVX with low-, medium-, and high-dose DOE (150, 300, and 600 mg/kg body weight/day, respectively). Animals in each group were administered their corresponding treatments for 13 weeks. Body weight, serum biochemical parameters, uterine and femoral physical parameters, bone mineral density (BMD), bone biomechanical properties, and bone microarchitecture were obtained. In vitro, the effects of DOE on osteoclastogenesis were examined using RAW264.7 cells. The effects of DOE on osteoclastogenesis and the expression of osteoclast-specific marker genes and proteins were determined. Results: DOE effectively ameliorated serum biochemical parameters, especially alleviated estradiol (E2) deficiency and maintained calcium and phosphorus homeostasis. DOE improved uterine and femoral physical parameters. In addition, DOE improved femoral BMD and biomechanical properties. DOE significantly ameliorated bone microarchitecture. Moreover, DOE inhibited osteoclastogenesis independent of its cytoxicity and suppressed the expression of osteoclast-specific marker genes and proteins. Conclusion: DOE can effectively prevent ovariectomy-induced bone loss in vivo and inhibit osteoclastogenesis in vitro." @default.
• W2783192036 created "2018-01-26" @default.
• W2783192036 creator A5004092071 @default.
• W2783192036 creator A5015195367 @default.
• W2783192036 creator A5016931059 @default.
• W2783192036 creator A5021557591 @default.
• W2783192036 creator A5056101783 @default.
• W2783192036 creator A5062050451 @default.
• W2783192036 creator A5066448103 @default.
• W2783192036 creator A5087929515 @default.
• W2783192036 date "2018-01-15" @default.
• W2783192036 modified "2023-10-13" @default.
• W2783192036 title "Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis in Vivo and Inhibits RANKL-Induced Osteoclast Differentiation in Vitro" @default.
• W2783192036 cites W1198495910 @default.
• W2783192036 cites W1515078540 @default.
• W2783192036 cites W1576996980 @default.
• W2783192036 cites W1990161029 @default.
• W2783192036 cites W1991694624 @default.
• W2783192036 cites W1995778942 @default.
• W2783192036 cites W2008437503 @default.
• W2783192036 cites W2013639066 @default.
• W2783192036 cites W2017659306 @default.
• W2783192036 cites W2029306313 @default.
• W2783192036 cites W2040480357 @default.
• W2783192036 cites W2050435911 @default.
• W2783192036 cites W2053310801 @default.
• W2783192036 cites W2053708763 @default.
• W2783192036 cites W2058697010 @default.
• W2783192036 cites W2073472143 @default.
• W2783192036 cites W2078409020 @default.
• W2783192036 cites W2081906741 @default.
• W2783192036 cites W2082597549 @default.
• W2783192036 cites W2086055862 @default.
• W2783192036 cites W2089543198 @default.
• W2783192036 cites W2093096027 @default.
• W2783192036 cites W2093252878 @default.
• W2783192036 cites W2095351363 @default.
• W2783192036 cites W2096130532 @default.
• W2783192036 cites W2114004260 @default.
• W2783192036 cites W2119221073 @default.
• W2783192036 cites W2125179710 @default.
• W2783192036 cites W2156267537 @default.
• W2783192036 cites W2157888202 @default.
• W2783192036 cites W2186841716 @default.
• W2783192036 cites W2197342635 @default.
• W2783192036 cites W2269839701 @default.
• W2783192036 cites W2289824237 @default.
• W2783192036 cites W2312380708 @default.
• W2783192036 cites W2331149957 @default.
• W2783192036 cites W2358527842 @default.
• W2783192036 cites W2366177390 @default.
• W2783192036 cites W2521508926 @default.
• W2783192036 cites W2577344795 @default.
• W2783192036 cites W2589414013 @default.
• W2783192036 cites W2593248083 @default.
• W2783192036 cites W2613177040 @default.
• W2783192036 cites W2618213894 @default.
• W2783192036 cites W2724724381 @default.
• W2783192036 cites W2738819725 @default.
• W2783192036 cites W2738919786 @default.
• W2783192036 cites W28943825 @default.
• W2783192036 cites W4229849486 @default.
• W2783192036 doi "https://doi.org/10.3389/fphar.2017.00966" @default.
• W2783192036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7204803" @default.
• W2783192036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32425797" @default.
• W2783192036 hasPublicationYear "2018" @default.
• W2783192036 type Work @default.
• W2783192036 sameAs 2783192036 @default.
• W2783192036 citedByCount "23" @default.
• W2783192036 countsByYear W27831920362019 @default.
• W2783192036 countsByYear W27831920362020 @default.
• W2783192036 countsByYear W27831920362021 @default.
• W2783192036 countsByYear W27831920362022 @default.
• W2783192036 countsByYear W27831920362023 @default.
• W2783192036 crossrefType "journal-article" @default.
• W2783192036 hasAuthorship W2783192036A5004092071 @default.
• W2783192036 hasAuthorship W2783192036A5015195367 @default.
• W2783192036 hasAuthorship W2783192036A5016931059 @default.
• W2783192036 hasAuthorship W2783192036A5021557591 @default.
• W2783192036 hasAuthorship W2783192036A5056101783 @default.
• W2783192036 hasAuthorship W2783192036A5062050451 @default.
• W2783192036 hasAuthorship W2783192036A5066448103 @default.
• W2783192036 hasAuthorship W2783192036A5087929515 @default.
• W2783192036 hasBestOaLocation W27831920361 @default.
• W2783192036 hasConcept C126322002 @default.
• W2783192036 hasConcept C134018914 @default.
• W2783192036 hasConcept C150903083 @default.
• W2783192036 hasConcept C170033053 @default.
• W2783192036 hasConcept C170493617 @default.
• W2783192036 hasConcept C207001950 @default.
• W2783192036 hasConcept C2776033226 @default.
• W2783192036 hasConcept C2776541429 @default.
• W2783192036 hasConcept C2776886416 @default.
• W2783192036 hasConcept C2777164284 @default.
• W2783192036 hasConcept C2779428903 @default.
• W2783192036 hasConcept C71924100 @default.
• W2783192036 hasConcept C8264082 @default.
• W2783192036 hasConcept C86803240 @default.
• W2783192036 hasConcept C88045685 @default.
• W2783192036 hasConcept C98274493 @default.

• next