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- W2783192114 abstract "Osteoporosis is a metabolic bone disease characterized by low bone mass and micro-architectural deterioration of bone, for which the underlying mechanism is an imbalance between bone resorption and bone remodeling. The protein-protein interactions between receptor activator of nuclear factor-κB ligand (RANKL), RANK (its receptor), and osteoprotegerin (OPG), are known to mediate the development and activation of osteoclasts in bone remodeling, and are regarded as a pivotal therapeutic target for the treatment of osteoporosis. Herein, we disclose the successful development of a novel glycopeptide (OM-2), the structure of which is based on the key interacting sites of the reported RANKL and OPG crystal structure. OM-2 exhibited potent binding affinity with RANKL and resistance to degradation by protease enzymes. It also blocked RANKL/RANK interactions, and inhibited osteoclastogenesis in vitro. In vivo studies confirmed that OM-2 could effectively reduce bone loss and inhibit osteoclast activation in ovariectomized (OVX) mice at a dosage of 20.0 mg/kg/day. Accordingly, OM-2 is suggested as a therapeutic candidate for postmenopausal osteoporosis (PMOP) and osteoclastogenesis-related diseases like rheumatoid arthritis (RA). More importantly, its identification validates our structure-based strategy for the development of drugs that target the RANKL/RANK/OPG system." @default.
- W2783192114 created "2018-01-26" @default.
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- W2783192114 date "2018-02-01" @default.
- W2783192114 modified "2023-10-14" @default.
- W2783192114 title "Structure-based development of an osteoprotegerin-like glycopeptide that blocks RANKL/RANK interactions and reduces ovariectomy-induced bone loss in mice" @default.
- W2783192114 cites W1504949814 @default.
- W2783192114 cites W1512686244 @default.
- W2783192114 cites W1534645474 @default.
- W2783192114 cites W1576677426 @default.
- W2783192114 cites W1642058051 @default.
- W2783192114 cites W1650001464 @default.
- W2783192114 cites W1923732536 @default.
- W2783192114 cites W1963491484 @default.
- W2783192114 cites W1964066819 @default.
- W2783192114 cites W1967615426 @default.
- W2783192114 cites W1972001482 @default.
- W2783192114 cites W1974090415 @default.
- W2783192114 cites W1975268574 @default.
- W2783192114 cites W1975364318 @default.
- W2783192114 cites W1975953388 @default.
- W2783192114 cites W1976717413 @default.
- W2783192114 cites W1977753585 @default.
- W2783192114 cites W1978455823 @default.
- W2783192114 cites W1989607165 @default.
- W2783192114 cites W1992450378 @default.
- W2783192114 cites W1994602643 @default.
- W2783192114 cites W1997585969 @default.
- W2783192114 cites W2000647744 @default.
- W2783192114 cites W2001808739 @default.
- W2783192114 cites W2008185727 @default.
- W2783192114 cites W2014241236 @default.
- W2783192114 cites W2015866089 @default.
- W2783192114 cites W2021008851 @default.
- W2783192114 cites W2022595186 @default.
- W2783192114 cites W2035416199 @default.
- W2783192114 cites W2036368043 @default.
- W2783192114 cites W2038351940 @default.
- W2783192114 cites W2045763430 @default.
- W2783192114 cites W2048964656 @default.
- W2783192114 cites W2052712126 @default.
- W2783192114 cites W2058858133 @default.
- W2783192114 cites W2061016312 @default.
- W2783192114 cites W2069658855 @default.
- W2783192114 cites W2070499759 @default.
- W2783192114 cites W2073112480 @default.
- W2783192114 cites W2074195300 @default.
- W2783192114 cites W2079640720 @default.
- W2783192114 cites W2085916791 @default.
- W2783192114 cites W2088678853 @default.
- W2783192114 cites W2100627513 @default.
- W2783192114 cites W2106751714 @default.
- W2783192114 cites W2106766464 @default.
- W2783192114 cites W2107789045 @default.
- W2783192114 cites W2111602211 @default.
- W2783192114 cites W2112629831 @default.
- W2783192114 cites W2113697838 @default.
- W2783192114 cites W2115075530 @default.
- W2783192114 cites W2117996911 @default.
- W2783192114 cites W2129826523 @default.
- W2783192114 cites W2131049610 @default.
- W2783192114 cites W2139996507 @default.
- W2783192114 cites W2157193896 @default.
- W2783192114 cites W2160005424 @default.
- W2783192114 cites W2160091290 @default.
- W2783192114 cites W2168614076 @default.
- W2783192114 cites W2170384111 @default.
- W2783192114 cites W2191072548 @default.
- W2783192114 cites W2321847772 @default.
- W2783192114 cites W2335178464 @default.
- W2783192114 cites W2470223656 @default.
- W2783192114 cites W2572299553 @default.
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- W2783192114 doi "https://doi.org/10.1016/j.ejmech.2018.01.022" @default.
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