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- W2783193454 abstract "Transfusion plays an important role in the management of patients with hematologicalmalignancies and disorders. Patients during the induction chemotherapy may need multipletransfusion of platelets and red cells and may develop refractoriness; platelet count incrementdeteriorate even after adequate dose of platelets are transfused. Although several studiesreported non-immunological factors like fever, Splenomegaly, septicemia and severe bleedingare responsible for refractoriness in some patients, no specific reasons can be found. This raisesthe suspicion of platelet antibodies for the cause of refractoriness. Till now in many studies, thepresence of HLA and platelet specific antibodies were found to be between 10%-60%in thepatients who were treated with multiple transfusions.Our results concluded that multiple random donor blood and platelet transfusion are ableto induce antibodies against HLA class 1 antigens and epitopes on GP iib/iiia. There was norelationship between the number of units transfused and the antibodies formation. Women withsingle pregnancy history were identified as high responder group for alloimmunization. Ourresults show AML are frequently immunized than ALL patients.Keeping in view the alloimmunization, leukoreduced irradiated single donor plateletsand blood components should be transfused for the treatment of hematological and oncologicalpatients. Till now, non-leukoreduced components are used in most of the centers in India due tocost of leukoreduction. Testing for the presence of platelet antibodies and transfusion ofcompatible platelets shall be important mode of management and prevention of plateletrefractoriness in India." @default.
- W2783193454 created "2018-01-26" @default.
- W2783193454 creator A5067663289 @default.
- W2783193454 date "2008-03-01" @default.
- W2783193454 modified "2023-09-27" @default.
- W2783193454 title "Platelet Alloantibody Specificities in Multiply Transfused Patients." @default.
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