Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783195856> ?p ?o ?g. }
- W2783195856 abstract "Context: Androgen deprivation therapy (ADT) is increasingly used for the treatment of prostate cancer (PCa), even in clinical settings in which there is no evidence-based proof of prolonged overall survival (OS). ADT, however, may be associated with numerous side effects, including an increased therapy-related cardiovascular mortality. Objective: To discuss different clinical settings in which ADT is currently used and to critically weigh the benefits of ADT against its possible side effects. Evidence acquisition: A MEDLINE search was conducted to identify original articles and review articles addressing the efficacy and side effects of ADT for the treatment of PCa. Keywords consisted of prostate cancer, hormonal therapy, adverse effects, radical prostatectomy, and radiotherapy. The articles with the highest level of evidence for the various examined end points were identified with the consensus of all authors and were reviewed. Evidence synthesis: Even short-term use of ADT may lead to numerous side effects, such as osteoporosis, obesity, sarcopenia, lipid alterations, insulin resistance, and increased risk for diabetes and cardiovascular morbidity. Despite these side effects, ADT is commonly used in various clinical settings in which a clear effect on improved OS has not been shown. Conclusions: ADT is associated with an increased risk of multiple side effects that may reduce quality of life and/or OS. Consequently, these issues should be discussed in detail with patients and their families before initiation of ADT. ADT should be used with knowledge of its potential long-term side effects and with possible lifestyle interventions, especially in settings with the highest risk–benefit ratio, to alleviate comorbidities." @default.
- W2783195856 created "2018-01-26" @default.
- W2783195856 creator A5001059521 @default.
- W2783195856 creator A5004985848 @default.
- W2783195856 creator A5017925159 @default.
- W2783195856 creator A5031111261 @default.
- W2783195856 creator A5056969058 @default.
- W2783195856 creator A5061623935 @default.
- W2783195856 creator A5075222976 @default.
- W2783195856 creator A5090255439 @default.
- W2783195856 date "2009-01-01" @default.
- W2783195856 modified "2023-09-27" @default.
- W2783195856 title "Collaborative Review - Prostate Cancer Androgen Deprivation Therapy for the Treatment of Prostate Cancer: Consider Both Benefits and Risks" @default.
- W2783195856 cites W1272283096 @default.
- W2783195856 cites W1504223662 @default.
- W2783195856 cites W1546246969 @default.
- W2783195856 cites W1602927683 @default.
- W2783195856 cites W1964360682 @default.
- W2783195856 cites W1968819399 @default.
- W2783195856 cites W1974256738 @default.
- W2783195856 cites W1975959565 @default.
- W2783195856 cites W1980224053 @default.
- W2783195856 cites W1980336089 @default.
- W2783195856 cites W1981441957 @default.
- W2783195856 cites W1985164813 @default.
- W2783195856 cites W1986404016 @default.
- W2783195856 cites W1987109043 @default.
- W2783195856 cites W1988223280 @default.
- W2783195856 cites W1992912488 @default.
- W2783195856 cites W1993493061 @default.
- W2783195856 cites W1997732940 @default.
- W2783195856 cites W1998046820 @default.
- W2783195856 cites W2005383842 @default.
- W2783195856 cites W2006286039 @default.
- W2783195856 cites W2008549629 @default.
- W2783195856 cites W2010528776 @default.
- W2783195856 cites W2011581813 @default.
- W2783195856 cites W2012774668 @default.
- W2783195856 cites W2019530713 @default.
- W2783195856 cites W2019661343 @default.
- W2783195856 cites W2020120231 @default.
- W2783195856 cites W2020130891 @default.
- W2783195856 cites W2020438145 @default.
- W2783195856 cites W2024266959 @default.
- W2783195856 cites W2025833867 @default.
- W2783195856 cites W2026345582 @default.
- W2783195856 cites W2029096189 @default.
- W2783195856 cites W2032462898 @default.
- W2783195856 cites W2035397440 @default.
- W2783195856 cites W2038299154 @default.
- W2783195856 cites W2052113230 @default.
- W2783195856 cites W2054745440 @default.
- W2783195856 cites W2056480857 @default.
- W2783195856 cites W2057288774 @default.
- W2783195856 cites W2061172474 @default.
- W2783195856 cites W2066722676 @default.
- W2783195856 cites W2070303233 @default.
- W2783195856 cites W2071879495 @default.
- W2783195856 cites W2073496706 @default.
- W2783195856 cites W2074421032 @default.
- W2783195856 cites W2075007329 @default.
- W2783195856 cites W2075606415 @default.
- W2783195856 cites W2077219580 @default.
- W2783195856 cites W2080960491 @default.
- W2783195856 cites W2082333541 @default.
- W2783195856 cites W2082966382 @default.
- W2783195856 cites W2085368059 @default.
- W2783195856 cites W2086247313 @default.
- W2783195856 cites W2086580973 @default.
- W2783195856 cites W2089396531 @default.
- W2783195856 cites W2089778115 @default.
- W2783195856 cites W2098998490 @default.
- W2783195856 cites W2103314990 @default.
- W2783195856 cites W2104749274 @default.
- W2783195856 cites W2105310697 @default.
- W2783195856 cites W2106458814 @default.
- W2783195856 cites W2107925414 @default.
- W2783195856 cites W2108743117 @default.
- W2783195856 cites W2109343166 @default.
- W2783195856 cites W2112080888 @default.
- W2783195856 cites W2117886818 @default.
- W2783195856 cites W2118310760 @default.
- W2783195856 cites W2119283349 @default.
- W2783195856 cites W2120862552 @default.
- W2783195856 cites W2120993630 @default.
- W2783195856 cites W2123230901 @default.
- W2783195856 cites W2123665339 @default.
- W2783195856 cites W2129509910 @default.
- W2783195856 cites W2129688420 @default.
- W2783195856 cites W2130607139 @default.
- W2783195856 cites W2134766389 @default.
- W2783195856 cites W2142359566 @default.
- W2783195856 cites W2142391938 @default.
- W2783195856 cites W2144312415 @default.
- W2783195856 cites W2144498681 @default.
- W2783195856 cites W2148539277 @default.
- W2783195856 cites W2149024777 @default.
- W2783195856 cites W2151114651 @default.
- W2783195856 cites W2154213268 @default.
- W2783195856 cites W2156549595 @default.