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• W2783196756 endingPage "129" @default.
• W2783196756 startingPage "119" @default.
• W2783196756 abstract "Human skin has a distinct profile of fatty acids and related bioactive lipid mediators that regulate many aspects of epidermal and dermal homeostasis, including immune and inflammatory reactions. Sebum lipids act as effective antimicrobial agents, shape immune cell communications and contribute to the epidermal lipidome. The essential fatty acid linoleic acid is crucial for the structure of the epidermal barrier, while polyunsaturated fatty acids act as precursors to eicosanoids, octadecanoids and docosanoids through cyclooxygenase, lipoxygenase and cytochrome P450 monooxygenase-mediated reactions, and endocannabinoids and N-acyl ethanolamines. Cross-communication between these families of bioactive lipids suggests that their cutaneous activities should be considered as part of a wider metabolic network that can be targeted to maintain skin health, control inflammation and improve skin pathologies." @default.
• W2783196756 created "2018-01-26" @default.
• W2783196756 creator A5005136730 @default.
• W2783196756 creator A5005286924 @default.
• W2783196756 creator A5054096812 @default.
• W2783196756 date "2018-01-12" @default.
• W2783196756 modified "2023-09-27" @default.
• W2783196756 title "Fatty acids and related lipid mediators in the regulation of cutaneous inflammation" @default.
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