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- W2783196772 abstract "Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic phospholipase A2 (cPLA2α) activity to prevent the release of arachidonic acid (AA), a TXA2 precursor, is unknown. In this study, we attempted to identify the mechanism underlying G-Ro-mediated TXA2 inhibition.We investigated whether G-Ro attenuates TXA2 production and its associated molecules, such as cyclooxygenase-1 (COX-1), TXA2 synthase (TXAS), cPLA2α, mitogen-activated protein kinases, and AA. To assay COX-1 and TXAS, we used microsomal fraction of platelets.G-Ro reduced TXA2 production by inhibiting AA release. It acted by decreasing the phosphorylation of cPLA2α, p38-mitogen-activated protein kinase, and c-Jun N-terminal kinase1, rather than by inhibiting COX-1 and TXAS in thrombin-activated human platelets.G-Ro inhibits AA release to attenuate TXA2 production, which may counteract TXA2-associated thrombosis." @default.
- W2783196772 created "2018-01-26" @default.
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- W2783196772 date "2019-04-01" @default.
- W2783196772 modified "2023-09-24" @default.
- W2783196772 title "Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release" @default.
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- W2783196772 doi "https://doi.org/10.1016/j.jgr.2017.12.007" @default.
- W2783196772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6437639" @default.
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