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- W2783197017 abstract "Understanding factors that regulate zygotic genome activation (ZGA) is critical for determining how cells are reprogrammed to become totipotent or pluripotent. There is limited information regarding how this process occurs physiologically in early mammalian embryos. Here, we identify a mediator complex subunit, MED13, as translated during mouse oocyte maturation and transcribed early from the zygotic genome. Knockdown and conditional knockout approaches demonstrate that MED13 is essential for ZGA in the mouse, in part by regulating expression of the embryo-specific chromatin remodeling complex, esBAF. The role of MED13 in ZGA is mediated in part by interactions with E2F transcription factors. In addition to MED13, its paralog, MED13L, is required for successful preimplantation embryo development. MED13L partially compensates for loss of MED13 function in preimplantation knockout embryos, but postimplantation development is not rescued by MED13L. Our data demonstrate an essential role for MED13 in supporting chromatin reprogramming and directed transcription of essential genes during ZGA." @default.
- W2783197017 created "2018-01-26" @default.
- W2783197017 creator A5003273569 @default.
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- W2783197017 date "2018-01-09" @default.
- W2783197017 modified "2023-10-14" @default.
- W2783197017 title "Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse†,‡" @default.
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- W2783197017 doi "https://doi.org/10.1093/biolre/ioy004" @default.
- W2783197017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279059" @default.
- W2783197017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29325037" @default.
- W2783197017 hasPublicationYear "2018" @default.
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