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• W2783200144 endingPage "e1007176" @default.
• W2783200144 startingPage "e1007176" @default.
• W2783200144 abstract "The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is not clear. Here, we use tandem affinity purification coupled with mass spectrometry to identify Wor1-interacting proteins. Tup1 and its associated complex proteins are found as the major factors associated with Wor1. Tup1 occupies the same regions of the WOR1 promoter as Wor1 preferentially in opaque cells. Loss of Tup1 is sufficient to induce the opaque phase, even in the absence of Wor1. This is the first such report of a bypass of Wor1 in opaque formation. These genetic analyses suggest that Tup1 is a key repressor of the opaque state, and Wor1 functions via alleviating Tup1 repression at the WOR1 promoter. Opaque cells convert to white en masse at 37°C. We show that this conversion occurs only in the presence of glycolytic carbon sources. The opaque state is stabilized when cells are cultured on non-glycolytic carbon sources, even in a MTLa/α background. We further show that temperature and carbon source affect opaque stability by altering the levels of Wor1 and Tup1 at the WOR1 promoter. We propose that Wor1 and Tup1 form the core regulatory circuit controlling the opaque transcriptional program. This model provides molecular insights on how C. albicans adapts to different host signals to undergo phenotypic switching for colonization in distinct host niches." @default.
• W2783200144 created "2018-01-26" @default.
• W2783200144 creator A5003593504 @default.
• W2783200144 creator A5004187953 @default.
• W2783200144 creator A5070754234 @default.
• W2783200144 creator A5088059869 @default.
• W2783200144 date "2018-01-16" @default.
• W2783200144 modified "2023-10-15" @default.
• W2783200144 title "Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans" @default.
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• W2783200144 doi "https://doi.org/10.1371/journal.pgen.1007176" @default.
• W2783200144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5786334" @default.
• W2783200144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29337983" @default.
• W2783200144 hasPublicationYear "2018" @default.
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