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• W2783201045 abstract "Residues responsible for allostery, cooperativity, and other subtle but functionally important interactions remain difficult to detect. To aid such detection, we employ statistical inference based on the assumption that residues distinguishing a protein subgroup from evolutionarily divergent subgroups often constitute an interacting functional network. We identify such networks with the aid of two measures of statistical significance. One measure aids identification of divergent subgroups based on distinguishing residue patterns. For each subgroup, a second measure identifies structural interactions involving pattern residues. Such interactions are derived either from atomic coordinates or from Direct Coupling Analysis scores, used as surrogates for structural distances. Applying this approach to N-acetyltransferases, P-loop GTPases, RNA helicases, synaptojanin-superfamily phosphatases and nucleases, and thymine/uracil DNA glycosylases yielded results congruent with biochemical understanding of these proteins, and also revealed striking sequence-structural features overlooked by other methods. These and similar analyses can aid the design of drugs targeting allosteric sites." @default.
• W2783201045 created "2018-01-26" @default.
• W2783201045 creator A5010571747 @default.
• W2783201045 creator A5015061000 @default.
• W2783201045 creator A5026932356 @default.
• W2783201045 date "2018-01-16" @default.
• W2783201045 modified "2023-09-29" @default.
• W2783201045 title "Inferring joint sequence-structural determinants of protein functional specificity" @default.
• W2783201045 cites W1580356236 @default.
• W2783201045 cites W1722029454 @default.
• W2783201045 cites W1759382455 @default.
• W2783201045 cites W1792645488 @default.
• W2783201045 cites W1927019480 @default.
• W2783201045 cites W1951660422 @default.
• W2783201045 cites W1965998064 @default.
• W2783201045 cites W1966651071 @default.
• W2783201045 cites W1968895302 @default.
• W2783201045 cites W1974093948 @default.
• W2783201045 cites W1982583124 @default.
• W2783201045 cites W1987753375 @default.
• W2783201045 cites W1993970354 @default.
• W2783201045 cites W1995924392 @default.
• W2783201045 cites W2004078029 @default.
• W2783201045 cites W2005614857 @default.
• W2783201045 cites W2006438342 @default.
• W2783201045 cites W2008545402 @default.
• W2783201045 cites W2010931041 @default.
• W2783201045 cites W2011450474 @default.
• W2783201045 cites W2023027197 @default.
• W2783201045 cites W2023385944 @default.
• W2783201045 cites W2023849570 @default.
• W2783201045 cites W2027036222 @default.
• W2783201045 cites W2027277444 @default.
• W2783201045 cites W2031901496 @default.
• W2783201045 cites W2034837718 @default.
• W2783201045 cites W2038862069 @default.
• W2783201045 cites W2041786544 @default.
• W2783201045 cites W2046298637 @default.
• W2783201045 cites W2056449835 @default.
• W2783201045 cites W2058941563 @default.
• W2783201045 cites W2059446387 @default.
• W2783201045 cites W2061042699 @default.
• W2783201045 cites W2066928877 @default.
• W2783201045 cites W2069100030 @default.
• W2783201045 cites W2071884450 @default.
• W2783201045 cites W2074479149 @default.
• W2783201045 cites W2075773498 @default.
• W2783201045 cites W2077167882 @default.
• W2783201045 cites W2079959721 @default.
• W2783201045 cites W2081741335 @default.
• W2783201045 cites W2092006899 @default.
• W2783201045 cites W2098958615 @default.
• W2783201045 cites W2100009368 @default.
• W2783201045 cites W2103660241 @default.
• W2783201045 cites W2104572985 @default.
• W2783201045 cites W2104601544 @default.
• W2783201045 cites W2104974597 @default.
• W2783201045 cites W2105157799 @default.
• W2783201045 cites W2106329053 @default.
• W2783201045 cites W2106383137 @default.
• W2783201045 cites W2112617940 @default.
• W2783201045 cites W2116589531 @default.
• W2783201045 cites W2118008176 @default.
• W2783201045 cites W2121714338 @default.
• W2783201045 cites W2123273725 @default.
• W2783201045 cites W2130027818 @default.
• W2783201045 cites W2131599797 @default.
• W2783201045 cites W2134043769 @default.
• W2783201045 cites W2135727668 @default.
• W2783201045 cites W2136495792 @default.
• W2783201045 cites W2136902941 @default.
• W2783201045 cites W2137991504 @default.
• W2783201045 cites W2138560091 @default.
• W2783201045 cites W2139919097 @default.
• W2783201045 cites W2141432903 @default.
• W2783201045 cites W2141757982 @default.
• W2783201045 cites W2141879010 @default.
• W2783201045 cites W2143004134 @default.
• W2783201045 cites W2149026172 @default.
• W2783201045 cites W2151100442 @default.
• W2783201045 cites W2151457629 @default.
• W2783201045 cites W2155507662 @default.
• W2783201045 cites W2155557083 @default.
• W2783201045 cites W2156571424 @default.
• W2783201045 cites W2158020463 @default.
• W2783201045 cites W2158714788 @default.
• W2783201045 cites W2160575754 @default.
• W2783201045 cites W2162566191 @default.
• W2783201045 cites W2162574056 @default.
• W2783201045 cites W2170249492 @default.
• W2783201045 cites W2254265832 @default.
• W2783201045 cites W2334350898 @default.
• W2783201045 cites W2360859268 @default.
• W2783201045 cites W2402064298 @default.
• W2783201045 cites W2414203456 @default.
• W2783201045 cites W2468040701 @default.
• W2783201045 cites W2515574711 @default.
• W2783201045 cites W2515712275 @default.
• W2783201045 cites W2518491015 @default.
• W2783201045 cites W2520187496 @default.

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