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• W2783201365 abstract "The wound healing is a complex process wherein inflammation, proliferation and regeneration evolve according to a spatio-temporal pattern from the activation of coagulation cascade to the formation of a plug clot including fibrin matrix, blood-borne cells and cytokines/growth factors. Creating environments conducive to tissue repair, the haemoderivatives are commonly proposed for the treatment of hard-to-heal wounds. Here, we explored in vitro the intrinsic regenerative potentialities of a leucocyte- and platelet-rich fibrin product, known as CPL-MB, defining the stemness grade of cells sprouting from the haemoderivative. Using highly concentrated serum-based medium to simulate wound conditions, we isolated fibroblast-like cells (CPL-CMCs) adhering to plastic and showing stable in vitro propagation, heterogeneous stem cell expression pattern, endothelial adhesive properties and immunomodulatory profile. Due to their blood derivation and expression of CXCR4, CPL-CMCs have been suggested to be immature cells circulating in peripheral blood at quiescent state until activation by both coagulation event and inflammatory stimuli such as stromal-derived factor 1/SDF1. Expressing integrins (CD49f, CD103), vascular adhesion molecules (CD106, CD166), endoglin (CD105) and remodelling matrix enzymes (MMP2, MMP9, MMP13), they showed a transendothelial migratory potential besides multipotency. Taken together, our data suggested that a standardized, reliable and economically feasible blood product such as CPL-MB functions as an artificial stem cell niche that, under permissive conditions, originate ex vivo immature cells that could be useful for autologous stem cell-based therapies." @default.
• W2783201365 created "2018-01-26" @default.
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• W2783201365 date "2018-01-05" @default.
• W2783201365 modified "2023-09-26" @default.
• W2783201365 title "Leucocyte and Platelet-rich Fibrin: a carrier of autologous multipotent cells for regenerative medicine" @default.
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• W2783201365 doi "https://doi.org/10.1111/jcmm.13468" @default.
• W2783201365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5824368" @default.
• W2783201365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29314633" @default.
• W2783201365 hasPublicationYear "2018" @default.
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