Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783202951> ?p ?o ?g. }
- W2783202951 endingPage "176" @default.
- W2783202951 startingPage "167" @default.
- W2783202951 abstract "Ion mobility–mass spectrometry (IM–MS) is an important addition to the analytical toolbox for the structural evaluation of proteins, and is enhancing many areas of biophysical analysis. Disease-associated proteins, including enzymes such as protein kinases, transcription factors exemplified by p53, and intrinsically disordered proteins, including those prone to aggregation, are all amenable to structural analysis by IM–MS. In this review we discuss how this powerful technique can be used to understand protein conformational dynamics and aggregation pathways, and in particular, the effect that small molecules, including clinically-relevant drugs, play in these processes. We also present examples of how IM–MS can be used as a relatively rapid screening strategy to evaluate the mechanisms and conformation-driven aspects of protein:ligand interactions." @default.
- W2783202951 created "2018-01-26" @default.
- W2783202951 creator A5017388215 @default.
- W2783202951 creator A5043941292 @default.
- W2783202951 creator A5077792072 @default.
- W2783202951 creator A5087784924 @default.
- W2783202951 date "2018-02-01" @default.
- W2783202951 modified "2023-10-16" @default.
- W2783202951 title "Understanding protein–drug interactions using ion mobility–mass spectrometry" @default.
- W2783202951 cites W1254760643 @default.
- W2783202951 cites W1581742832 @default.
- W2783202951 cites W1630032692 @default.
- W2783202951 cites W1815123431 @default.
- W2783202951 cites W1956276313 @default.
- W2783202951 cites W1964918396 @default.
- W2783202951 cites W1969165181 @default.
- W2783202951 cites W1975159572 @default.
- W2783202951 cites W1981310330 @default.
- W2783202951 cites W1981583065 @default.
- W2783202951 cites W1981707733 @default.
- W2783202951 cites W1984951342 @default.
- W2783202951 cites W1986521396 @default.
- W2783202951 cites W1989948422 @default.
- W2783202951 cites W1990966474 @default.
- W2783202951 cites W1991634503 @default.
- W2783202951 cites W1992505804 @default.
- W2783202951 cites W1996420077 @default.
- W2783202951 cites W2001827418 @default.
- W2783202951 cites W2009556855 @default.
- W2783202951 cites W2011134129 @default.
- W2783202951 cites W2011432577 @default.
- W2783202951 cites W2012053348 @default.
- W2783202951 cites W2012453070 @default.
- W2783202951 cites W2018871138 @default.
- W2783202951 cites W2019812098 @default.
- W2783202951 cites W2025807025 @default.
- W2783202951 cites W2026183640 @default.
- W2783202951 cites W2028726006 @default.
- W2783202951 cites W2038255857 @default.
- W2783202951 cites W2042663659 @default.
- W2783202951 cites W2045579951 @default.
- W2783202951 cites W2053866466 @default.
- W2783202951 cites W2054970390 @default.
- W2783202951 cites W2055030223 @default.
- W2783202951 cites W2056544504 @default.
- W2783202951 cites W2057020790 @default.
- W2783202951 cites W2058906815 @default.
- W2783202951 cites W2059621776 @default.
- W2783202951 cites W2059903043 @default.
- W2783202951 cites W2068820645 @default.
- W2783202951 cites W2068834560 @default.
- W2783202951 cites W2069071040 @default.
- W2783202951 cites W2084966853 @default.
- W2783202951 cites W2086145691 @default.
- W2783202951 cites W2088180986 @default.
- W2783202951 cites W2088546850 @default.
- W2783202951 cites W2090630809 @default.
- W2783202951 cites W2096878195 @default.
- W2783202951 cites W2099778899 @default.
- W2783202951 cites W2102574135 @default.
- W2783202951 cites W2104265970 @default.
- W2783202951 cites W2114471971 @default.
- W2783202951 cites W2126160318 @default.
- W2783202951 cites W2126924389 @default.
- W2783202951 cites W2128113703 @default.
- W2783202951 cites W2132720084 @default.
- W2783202951 cites W2133013796 @default.
- W2783202951 cites W2135378461 @default.
- W2783202951 cites W2135590784 @default.
- W2783202951 cites W2136310648 @default.
- W2783202951 cites W2138014620 @default.
- W2783202951 cites W2153214177 @default.
- W2783202951 cites W2160415437 @default.
- W2783202951 cites W2160761064 @default.
- W2783202951 cites W2168822202 @default.
- W2783202951 cites W2170494099 @default.
- W2783202951 cites W2176467806 @default.
- W2783202951 cites W2178835883 @default.
- W2783202951 cites W2275695574 @default.
- W2783202951 cites W2289184477 @default.
- W2783202951 cites W2296995867 @default.
- W2783202951 cites W2316562377 @default.
- W2783202951 cites W2317233863 @default.
- W2783202951 cites W2319935708 @default.
- W2783202951 cites W2326825336 @default.
- W2783202951 cites W2329027920 @default.
- W2783202951 cites W2334348545 @default.
- W2783202951 cites W2335026087 @default.
- W2783202951 cites W2346688491 @default.
- W2783202951 cites W2407779851 @default.
- W2783202951 cites W2412083062 @default.
- W2783202951 cites W2486223135 @default.
- W2783202951 cites W2486245907 @default.
- W2783202951 cites W2508767729 @default.
- W2783202951 cites W2510615648 @default.
- W2783202951 cites W2524204318 @default.
- W2783202951 cites W254427209 @default.
- W2783202951 cites W2558396410 @default.