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• W2783203037 startingPage "173" @default.
• W2783203037 abstract "The paradoxical response of Streptococcus sanguinis to drugs prescribed for dental and clinical practices has complicated treatment guidelines and raised the need for further investigation. We conducted a high throughput study on concomitant transcriptome and proteome dynamics in a time course to assess S. sanguinis behaviour under a sub-inhibitory concentration of ampicillin. Temporal changes at the transcriptome and proteome level were monitored to cover essential genes and proteins over a physiological map of intricate pathways. Our findings revealed that translation was the functional category in S. sanguinis that was most enriched in essential proteins. Moreover, essential proteins in this category demonstrated the greatest conservation across 2774 bacterial proteomes, in comparison to other essential functional categories like cell wall biosynthesis and energy production. In comparison to non-essential proteins, essential proteins were less likely to contain ‘degradation-prone’ amino acids at their N-terminal position, suggesting a longer half-life. Despite the ampicillin-induced stress, the transcriptional up-regulation of amino acid-tRNA synthetases and proteomic elevation of amino acid biosynthesis enzymes favoured the enriched components of essential proteins revealing ‘proteomic signatures’ that can be used to bridge the genotype–phenotype gap of S. sanguinis under ampicillin stress. Furthermore, we identified a significant correlation between the levels of mRNA and protein for essential genes and detected essential protein-enriched pathways differentially regulated through a persistent stress response pattern at late time points. We propose that the current findings will help characterize a bacterial model to study the dynamics of essential genes and proteins under clinically relevant stress conditions." @default.
• W2783203037 created "2018-01-26" @default.
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• W2783203037 date "2018-02-01" @default.
• W2783203037 modified "2023-09-25" @default.
• W2783203037 title "Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis" @default.
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• W2783203037 doi "https://doi.org/10.1099/mic.0.000595" @default.
• W2783203037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5882076" @default.
• W2783203037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29393020" @default.
• W2783203037 hasPublicationYear "2018" @default.
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