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- W2783208141 endingPage "2733" @default.
- W2783208141 startingPage "2717" @default.
- W2783208141 abstract "Abstract Mitochondria are pivotal organelles in calcium (Ca 2+ ) handling and signalling, constituting intracellular checkpoints for numerous processes that are vital for cell life. Alterations in mitochondrial Ca 2+ homeostasis have been linked to a variety of pathological conditions and are critical in the aetiology of several human diseases. Efforts have been taken to harness mitochondrial Ca 2+ transport mechanisms for therapeutic intervention, but pharmacological compounds that direct and selectively modulate mitochondrial Ca 2+ homeostasis are currently lacking. New avenues have, however, emerged with the breakthrough discoveries on the genetic identification of the main players involved in mitochondrial Ca 2+ influx and efflux pathways and with recent hints towards a deep understanding of the function of these molecular systems. Here, we review the current advances in the understanding of the mechanisms and regulation of mitochondrial Ca 2+ homeostasis and its contribution to physiology and human disease. We also introduce and comment on the recent progress towards a systems‐level pharmacological targeting of mitochondrial Ca 2+ homeostasis. image" @default.
- W2783208141 created "2018-01-26" @default.
- W2783208141 creator A5049223262 @default.
- W2783208141 creator A5060915659 @default.
- W2783208141 date "2018-02-18" @default.
- W2783208141 modified "2023-10-10" @default.
- W2783208141 title "Pharmacological modulation of mitochondrial calcium homeostasis" @default.
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