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- W2783218242 endingPage "R683" @default.
- W2783218242 startingPage "R667" @default.
- W2783218242 abstract "Redox biology has become a major issue in numerous areas of physiology. Reactive oxygen species (ROS) have a broad range of roles from signal transduction to growth control and cell death. To understand the nature of these roles, accurate measurement of the reactive compounds is required. An increasing number of tools for ROS detection is available; however, the specificity and sensitivity of these tools are often insufficient. Furthermore, their specificity has been rarely evaluated in complex physiological conditions. Many ROS probes are sensitive to environmental conditions in particular pH, which may interfere with ROS detection and cause misleading results. Accurate detection of ROS in physiology and pathophysiology faces additional challenges concerning the precise localization of the ROS and the timing of their production and disappearance. Certain ROS are membrane permeable, and certain ROS probes move across cells and organelles. Targetable ROS probes such as fluorescent protein-based biosensors are required for accurate localization. Here we analyze these challenges in more detail, provide indications on the strength and weakness of current tools for ROS detection, and point out developments that will provide improved ROS detection methods in the future. There is no universal method that fits all situations in physiology and cell biology. A detailed knowledge of the ROS probes is required to choose the appropriate method for a given biological problem. The knowledge of the shortcomings of these probes should also guide the development of new sensors." @default.
- W2783218242 created "2018-01-26" @default.
- W2783218242 creator A5016705115 @default.
- W2783218242 creator A5023486091 @default.
- W2783218242 creator A5033135082 @default.
- W2783218242 date "2018-05-01" @default.
- W2783218242 modified "2023-10-10" @default.
- W2783218242 title "Biosensors for spatiotemporal detection of reactive oxygen species in cells and tissues" @default.
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