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• W2783223036 abstract "// Danfeng Zhang 1 * , Jigang Chen 1 * , Zhenxing Li 1 * , Junyu Wang 1 , Kaiwei Han 1 and Lijun Hou 1 1 Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China * These authors contributed equally to this work Correspondence to: Lijun Hou, email: lijunhoucz@126.com Kaiwei Han, email: toi@163.com Junyu Wang, email: jerome2008@163.com Keywords: nonfunctioning giant pituitary adenomas; hydrocephalus; clinical features; management; surgical approach Received: July 31, 2017      Accepted: December 05, 2017      Epub: January 11, 2018      Published: March 16, 2018 ABSTRACT We evaluated the features of clinically nonfunctioning giant pituitary adenomas (NFGPAs) causing hydrocephalus to highlight the timing of hydrocephalus management and surgical approaches. A total of 24 patients with NFGPAs and hydrocephalus were included. Eighteen patients underwent endoscopic transsphenoidal surgery. Ten patients received pterional surgery, including 6 patients as first treatment and 4 cases with recurrence after transsphenoidal approach. Gross total resection was achieved in 10 patients, including 6 cases (6/18, 33.3%) with endoscopic transsphenoidal surgery and 4 cases (4/10, 40%) with pterional surgery. All patients were divided into preoperative EVD group and non-preopoerative EVD group. The proportion of patients receiving postoperative EVD or shunt was significantly higher in non-preoperative EVD group than that in preoperative EVD group (9/15 vs. 1/9, P = 0.033). Visual impairment score (VIS) was evaluated for each patient. We detected significant vision improvement according to the preoperative and postoperative VIS (median, interquartile range: 62, 48.25–77 vs. 36.5, 0–50.75, P < 0.001). Conclusively, for patients with NFGPAs and hydrocephalus, preoperative EVD might reduce the need for a second shunt or EVD. Surgical approach should be decided based on the clinicoradiological features and surgeons’ experience for individualized treatment, and endoscopic transsphenoidal resection of pituitary adenomas was suggested for most NFGPAs." @default.
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• W2783223036 date "2018-01-11" @default.
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• W2783223036 title "Clinical features and management of nonfunctioning giant pituitary adenomas causing hydrocephalus" @default.
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• W2783223036 doi "https://doi.org/10.18632/oncotarget.24171" @default.
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