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• W2783223503 abstract "Autologous stem cell transplantation (ASCT) has been employed for patients with relapsed multiple myeloma (MM) after up-front ASCT. The present retrospective study aimed to examine the survival benefit from salvage ASCT. Among 446 patients with relapsed MM after up-front single ASCT, 70 patients received salvage ASCT, the employment of which reduced the risk of mortality after relapse (<i>p</i> = 0.041). Using the parameters before initial ASCT, the advantage of salvage ASCT compared to standard therapy was confirmed in the subgroup with an international staging system stage of I or II (<i>p</i> = 0.040), good performance status (PS; <i>p</i> = 0.043), or no/mild renal comorbidity (<i>p</i> = 0.029). The advantage of salvage ASCT was also confirmed in the subgroup excluding those with early relapse within 7 months after initial ASCT (<i>p</i> = 0.026). Among patients who received salvage ASCT, a favorable prognosis is apparent for those with a time to relapse after initial ASCT of longer than 24 months. The overall survival after salvage ASCT was favorable excluding patients with the following factors: early relapse, poor PS, moderate/severe renal comorbidity, and progressive disease (<i>p</i> < 0.001). In conclusion,<b> </b>our results reinforced the evidence for encouraging salvage ASCT for eligible patients." @default.
• W2783223503 created "2018-01-26" @default.
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• W2783223503 date "2018-01-01" @default.
• W2783223503 modified "2023-09-26" @default.
• W2783223503 title "Significance of Salvage Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma: A Nationwide Retrospective Study in Japan" @default.
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• W2783223503 doi "https://doi.org/10.1159/000484652" @default.
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