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- W2783226850 abstract "The purpose of the present work is to study the effect of different polymers and additives on thefelodipine USP of strength 10 mg comparable to the branded product PLENDILTo accomplish the objective API characterization and reference product evaluation was carriedout.The drug and the excipient were subjected to preformulation studies, which encompasses theDrug excipient compatibility.Wet granulation technique was chosen to develop a finished pharmaceutical product ofenvisaged form. Various formulations (F1-F13) were taken.In these formulations, Drug excipientratio was varied and the effect of polymers and Binder on the performance of the both blend aswell as tablets was studied.The formulation F1 which has no HPC and has only Methocel 100LVCR showed poor releasecharacteristics and formulation F2 which has HPC high viscosity grade showed a slightly betterprofile where as F3 which has HPC low viscosity grade shoed a profile which matches with thatof the innovator.The formulation F4 and F5,F4 which has Methocel 100 LVCR at a higher concentrationshowed less release when compared with F3 where as F5 which has a lower concentration of thesame polymer showed a higher releaseThe formulation F6 which has Methocel E 50 releases a higher amount of the drug whencompared with F3 where as the drug release from F7 which has MethocelK4MCR was very low.In the formulation F8,F9 and F10, it can be seen that F8, which did not have Cremophor the drug release was very poor." @default.
- W2783226850 created "2018-01-26" @default.
- W2783226850 creator A5039573429 @default.
- W2783226850 date "2012-03-01" @default.
- W2783226850 modified "2023-09-26" @default.
- W2783226850 title "Effect of Different Polymers and Additives on Felodipine USP Extended Release Tablets" @default.
- W2783226850 hasPublicationYear "2012" @default.
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