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• W2783228252 abstract "<b><i>Background:</i></b> Intracranial arterial calcification (IAC), a recognized marker of atherosclerosis on cranial computed tomography (CT), is an independent risk factor for ischaemic stroke. This study aimed to determine the prevalence, distribution, severity, and associations of IAC in adults with acute ischaemic stroke (AIS) at the University College Hospital, Ibadan, Nigeria.<b><i> Methods:</i></b> Cranial CT images of 130 consecutive adults who presented with AIS were acquired on a 64-slice multi-detector Toshiba Aquilion scanner and evaluated for IAC in bone window on Vitrea® software using a semi-quantitative scoring method for extent, thickness, and length of calcifications in the large intracranial arteries. Associations of IAC with clinical and laboratory data were determined by statistical analysis at <i>p</i> &#x3c; 0.05. <b><i>Results:</i></b> There were 71 males (54.6%), and the mean age of all patients was 63.0 ± 13.2 years. Hypertension was the most common risk factor (83.1%). IAC was found in 121 patients (93.1%), predominantly in the carotid siphon (86.1%) followed by the intracranial vertebral arteries (9.3%), middle cerebral arteries (2.4%), basilar artery (1.2%), and the anterior cerebral arteries (1%). The burden of IAC ranged from mild (17.4%) to moderate (52.1%) to severe (30.6%). Age (<i>p</i> &#x3c; 0.001), diastolic blood pressure (<i>p</i> = 0.037), and alcohol use (0.046) were significantly different among the patients with mild, moderate, and severe degrees of IAC. IAC was associated with age (<i>p</i> &#x3c; 0.001), hypertension (<i>p</i> = 0.03), diabetes mellitus (<i>p</i> = 0.02), hyperlipidaemia (<i>p</i> = 0.04), and alcohol use (<i>p</i> &#x3c; 0.001) but not with sex (<i>p</i> = 0.35). <b><i>Conclusions:</i></b> The burden of IAC is very high among native African patients with AIS and preferentially involves proximal inflow arteries. Therefore, the role of large vessel atherosclerosis in ischaemic stroke in native Africans should be explored in future multinational, multimodality studies." @default.
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• W2783228252 date "2018-01-15" @default.
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• W2783228252 title "Intracranial Arterial Calcification in Black Africans with Acute Ischaemic Stroke" @default.
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• W2783228252 doi "https://doi.org/10.1159/000485195" @default.
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