Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783231679> ?p ?o ?g. }
- W2783231679 endingPage "1025" @default.
- W2783231679 startingPage "1015" @default.
- W2783231679 abstract "Cerebral microbleeds (CMBs) could contribute to cognitive impairment in the general population and in patients with dementia. We designed a study to (i) develop a murine model of CMBs, (ii) assess whether CMBs affect cognition in this model and (iii) assess whether this model is sensitive to pharmacological modulation. Male C57Bl6/J mice were stereotactically administered collagenase to induce cortical lesion analysed by MRI at 24 h. CMB-mice were assessed at six weeks post-lesion for cognitive performances (Barnes maze and Touchscreen automated paired-associated learning (PAL) task) and for cerebral metabolism (in vivo PET/CT with fluorodeoxyglucose (FDG)). CMB-model sensitivity to pharmacological modulation was assessed by administering atorvastatin (5 mg/kg/day) over the follow-up period. CMB mice were compared to naïve littermates. Collagenase at 0.8 µU/µl appeared suitable to induce reproducible and reliable CMBs. At six weeks, a decline in learning, spatial and visuospatial memory was significantly observed in CMB-mice. Brain metabolism was impaired in all cortex, striatum and the ipsilateral dentate gyrus. A significant improvement in cognition performances was depicted under atorvastatin. In this novel murine model of CMBs, we validated that CMBs lowered cognitive performances and affected regional metabolism. We also proved that this CMB-model is sensitive to pharmacological modulation." @default.
- W2783231679 created "2018-01-26" @default.
- W2783231679 creator A5008481350 @default.
- W2783231679 creator A5017322608 @default.
- W2783231679 creator A5020584849 @default.
- W2783231679 creator A5029165551 @default.
- W2783231679 creator A5042886663 @default.
- W2783231679 creator A5055524428 @default.
- W2783231679 creator A5063862250 @default.
- W2783231679 creator A5068289228 @default.
- W2783231679 creator A5068415897 @default.
- W2783231679 creator A5074836495 @default.
- W2783231679 creator A5074944516 @default.
- W2783231679 creator A5079246880 @default.
- W2783231679 creator A5084467929 @default.
- W2783231679 date "2018-01-15" @default.
- W2783231679 modified "2023-10-01" @default.
- W2783231679 title "Role of cortical microbleeds in cognitive impairment: In vivo behavioral and imaging characterization of a novel murine model" @default.
- W2783231679 cites W1542438573 @default.
- W2783231679 cites W1561835828 @default.
- W2783231679 cites W1978178338 @default.
- W2783231679 cites W1992608632 @default.
- W2783231679 cites W1993569783 @default.
- W2783231679 cites W2014640272 @default.
- W2783231679 cites W2017024863 @default.
- W2783231679 cites W2054288026 @default.
- W2783231679 cites W2073104240 @default.
- W2783231679 cites W2074945021 @default.
- W2783231679 cites W2100167607 @default.
- W2783231679 cites W2104046215 @default.
- W2783231679 cites W2108882135 @default.
- W2783231679 cites W2111645838 @default.
- W2783231679 cites W2137115974 @default.
- W2783231679 cites W2145396188 @default.
- W2783231679 cites W2148568506 @default.
- W2783231679 cites W2151343738 @default.
- W2783231679 cites W2155041116 @default.
- W2783231679 cites W2161008294 @default.
- W2783231679 cites W2161957546 @default.
- W2783231679 cites W2165082682 @default.
- W2783231679 cites W2168134820 @default.
- W2783231679 cites W2278814217 @default.
- W2783231679 cites W2302900085 @default.
- W2783231679 cites W2354779203 @default.
- W2783231679 cites W2404276022 @default.
- W2783231679 cites W2409431643 @default.
- W2783231679 cites W2471977134 @default.
- W2783231679 cites W2514506319 @default.
- W2783231679 cites W2515130689 @default.
- W2783231679 cites W2520495506 @default.
- W2783231679 cites W2521389541 @default.
- W2783231679 cites W2549218657 @default.
- W2783231679 cites W2597038151 @default.
- W2783231679 cites W2610536118 @default.
- W2783231679 cites W2617433984 @default.
- W2783231679 cites W56476525 @default.
- W2783231679 doi "https://doi.org/10.1177/0271678x17752765" @default.
- W2783231679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6547192" @default.
- W2783231679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29333917" @default.
- W2783231679 hasPublicationYear "2018" @default.
- W2783231679 type Work @default.
- W2783231679 sameAs 2783231679 @default.
- W2783231679 citedByCount "10" @default.
- W2783231679 countsByYear W27832316792018 @default.
- W2783231679 countsByYear W27832316792019 @default.
- W2783231679 countsByYear W27832316792020 @default.
- W2783231679 countsByYear W27832316792021 @default.
- W2783231679 countsByYear W27832316792023 @default.
- W2783231679 crossrefType "journal-article" @default.
- W2783231679 hasAuthorship W2783231679A5008481350 @default.
- W2783231679 hasAuthorship W2783231679A5017322608 @default.
- W2783231679 hasAuthorship W2783231679A5020584849 @default.
- W2783231679 hasAuthorship W2783231679A5029165551 @default.
- W2783231679 hasAuthorship W2783231679A5042886663 @default.
- W2783231679 hasAuthorship W2783231679A5055524428 @default.
- W2783231679 hasAuthorship W2783231679A5063862250 @default.
- W2783231679 hasAuthorship W2783231679A5068289228 @default.
- W2783231679 hasAuthorship W2783231679A5068415897 @default.
- W2783231679 hasAuthorship W2783231679A5074836495 @default.
- W2783231679 hasAuthorship W2783231679A5074944516 @default.
- W2783231679 hasAuthorship W2783231679A5079246880 @default.
- W2783231679 hasAuthorship W2783231679A5084467929 @default.
- W2783231679 hasBestOaLocation W27832316791 @default.
- W2783231679 hasConcept C126322002 @default.
- W2783231679 hasConcept C142724271 @default.
- W2783231679 hasConcept C15744967 @default.
- W2783231679 hasConcept C169760540 @default.
- W2783231679 hasConcept C2776791281 @default.
- W2783231679 hasConcept C2776914184 @default.
- W2783231679 hasConcept C2779134260 @default.
- W2783231679 hasConcept C2779483572 @default.
- W2783231679 hasConcept C2779830541 @default.
- W2783231679 hasConcept C2780062018 @default.
- W2783231679 hasConcept C2781161787 @default.
- W2783231679 hasConcept C2908647359 @default.
- W2783231679 hasConcept C2984863031 @default.
- W2783231679 hasConcept C513476851 @default.
- W2783231679 hasConcept C71924100 @default.