Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783233297> ?p ?o ?g. }
- W2783233297 endingPage "251" @default.
- W2783233297 startingPage "251" @default.
- W2783233297 abstract "Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion molecules. The primary AML cells express various integrins. These heterodimeric molecules containing an α and a β chain are cell surface molecules that bind extracellular matrix molecules, cell surface molecules and soluble mediators. The β3 integrin (ITGB3) chain can form heterodimers only with the two α chains αIIb and αV. These integrins are among the most promiscuous and bind to a large number of ligands, including extracellular matrix molecules, cell surface molecules and soluble mediators. Recent studies suggest that the two β3 integrins are important for leukemogenesis and chemosensitivity in human AML. Firstly, αIIb and β3 are both important for adhesion of AML cells to vitronectin and fibronectin. Secondly, β3 is important for the development of murine AML and also for the homing and maintenance of the proliferation for xenografted primary human AML cells, and for maintaining a stem cell transcriptional program. These last effects seem to be mediated through Syk kinase. The β3 expression seems to be regulated by HomeboxA9 (HoxA9) and HoxA10, and the increased β3 expression then activates spleen tyrosine kinase (Syk) and thereby contributes to cytokine hypersensitivity and activation of β2 integrins. Finally, high integrin αV/β3 expression is associated with an adverse prognosis in AML and decreased sensitivity to the kinase inhibitor sorafenib; this integrin can also be essential for osteopontin-induced sorafenib resistance in AML. In the present article, we review the experimental and clinical evidence for a role of β3 integrins for leukemogenesis and chemosensitivity in AML." @default.
- W2783233297 created "2018-01-26" @default.
- W2783233297 creator A5021294750 @default.
- W2783233297 creator A5028830320 @default.
- W2783233297 creator A5046048174 @default.
- W2783233297 creator A5069016700 @default.
- W2783233297 creator A5083558574 @default.
- W2783233297 date "2018-01-15" @default.
- W2783233297 modified "2023-10-17" @default.
- W2783233297 title "The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia" @default.
- W2783233297 cites W1482797406 @default.
- W2783233297 cites W1489320608 @default.
- W2783233297 cites W1494085200 @default.
- W2783233297 cites W1533675232 @default.
- W2783233297 cites W1539930914 @default.
- W2783233297 cites W1576773659 @default.
- W2783233297 cites W1763573378 @default.
- W2783233297 cites W1907944232 @default.
- W2783233297 cites W1920120431 @default.
- W2783233297 cites W1959848155 @default.
- W2783233297 cites W1964876958 @default.
- W2783233297 cites W1968611056 @default.
- W2783233297 cites W1970483666 @default.
- W2783233297 cites W1976021347 @default.
- W2783233297 cites W1982901636 @default.
- W2783233297 cites W1990911008 @default.
- W2783233297 cites W1992124982 @default.
- W2783233297 cites W1993957513 @default.
- W2783233297 cites W1998929837 @default.
- W2783233297 cites W1998973639 @default.
- W2783233297 cites W2003256954 @default.
- W2783233297 cites W2004872298 @default.
- W2783233297 cites W2006286114 @default.
- W2783233297 cites W2006748134 @default.
- W2783233297 cites W2007501886 @default.
- W2783233297 cites W2011445722 @default.
- W2783233297 cites W2014644181 @default.
- W2783233297 cites W2015050458 @default.
- W2783233297 cites W2028936731 @default.
- W2783233297 cites W2031035635 @default.
- W2783233297 cites W2034876218 @default.
- W2783233297 cites W2038557641 @default.
- W2783233297 cites W2046800200 @default.
- W2783233297 cites W2047700126 @default.
- W2783233297 cites W2050531862 @default.
- W2783233297 cites W2059099697 @default.
- W2783233297 cites W2061733131 @default.
- W2783233297 cites W2065264929 @default.
- W2783233297 cites W2067771641 @default.
- W2783233297 cites W2072478240 @default.
- W2783233297 cites W2073874802 @default.
- W2783233297 cites W2080185771 @default.
- W2783233297 cites W2081467680 @default.
- W2783233297 cites W2086490690 @default.
- W2783233297 cites W2088651989 @default.
- W2783233297 cites W2095713258 @default.
- W2783233297 cites W2098676216 @default.
- W2783233297 cites W2101206043 @default.
- W2783233297 cites W2101244168 @default.
- W2783233297 cites W2107130264 @default.
- W2783233297 cites W2120426759 @default.
- W2783233297 cites W2139673903 @default.
- W2783233297 cites W2144436544 @default.
- W2783233297 cites W2145438823 @default.
- W2783233297 cites W2153641896 @default.
- W2783233297 cites W2154378559 @default.
- W2783233297 cites W2156807794 @default.
- W2783233297 cites W2159702756 @default.
- W2783233297 cites W2165400873 @default.
- W2783233297 cites W2166830291 @default.
- W2783233297 cites W2234994658 @default.
- W2783233297 cites W2249048097 @default.
- W2783233297 cites W2328701990 @default.
- W2783233297 cites W2339658711 @default.
- W2783233297 cites W2340909115 @default.
- W2783233297 cites W2403188976 @default.
- W2783233297 cites W2410626646 @default.
- W2783233297 cites W2416505888 @default.
- W2783233297 cites W2432843722 @default.
- W2783233297 cites W2467476141 @default.
- W2783233297 cites W2520809168 @default.
- W2783233297 cites W2536745143 @default.
- W2783233297 cites W2559537906 @default.
- W2783233297 cites W2567191869 @default.
- W2783233297 cites W2570993395 @default.
- W2783233297 cites W2586162879 @default.
- W2783233297 cites W2594417498 @default.
- W2783233297 cites W2607287498 @default.
- W2783233297 cites W2626358972 @default.
- W2783233297 cites W2708880998 @default.
- W2783233297 cites W2726135378 @default.
- W2783233297 cites W2747776510 @default.
- W2783233297 cites W3116048806 @default.
- W2783233297 cites W314540966 @default.
- W2783233297 cites W3189920043 @default.
- W2783233297 cites W4231346141 @default.
- W2783233297 cites W4238195539 @default.
- W2783233297 cites W4241652217 @default.