FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783233751> ?p ?o ?g. }

• W2783233751 abstract "Plumbagin, an anti-cancer agent, is toxic to cells of multiple species. We investigated if plumbagin targets conserved biochemical processes. Plumbagin induced DNA damage and apoptosis in cells of diverse mutational background with comparable potency. A 3-5 fold increase in intracellular oxygen radicals occurred in response to plumbagin. Neutralization of the reactive oxygen species by N-acetylcysteine blocked apoptosis, indicating a central role for oxidative stress in plumbagin-mediated cell death. Plumbagin docks in the ubiquinone binding sites (Q0 and Qi) of mitochondrial complexes I-III, the major sites for oxygen radicals. Plumbagin decreased oxygen consumption rate, ATP production and optical redox ratio (NAD(P)H/FAD) indicating interference with electron transport downstream of mitochondrial Complex II. Oxidative stress induced by plumbagin triggered an anti-oxidative response via activation of Nrf2. Plumbagin and the Nrf2 inhibitor, brusatol, synergized to inhibit cell proliferation. These data indicate that while inhibition of electron transport is the conserved mechanism responsible for plumbagin's chemotoxicity, activation of Nrf2 is the resulting anti-oxidative response that allows plumbagin to serve as a chemopreventive agent. This study provides the basis for designing potent and selective plumbagin analogs that can be coupled with suitable Nrf2 inhibitors for chemotherapy or administered as single agents to induce Nrf2-mediated chemoprevention." @default.
• W2783233751 created "2018-01-26" @default.
• W2783233751 creator A5009470791 @default.
• W2783233751 creator A5013987582 @default.
• W2783233751 creator A5024496300 @default.
• W2783233751 creator A5026689823 @default.
• W2783233751 creator A5027080762 @default.
• W2783233751 creator A5049773860 @default.
• W2783233751 creator A5054861531 @default.
• W2783233751 creator A5061916566 @default.
• W2783233751 creator A5065740817 @default.
• W2783233751 creator A5077068011 @default.
• W2783233751 creator A5082222066 @default.
• W2783233751 creator A5084628898 @default.
• W2783233751 date "2018-01-18" @default.
• W2783233751 modified "2023-09-25" @default.
• W2783233751 title "Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin" @default.
• W2783233751 cites W1239714022 @default.
• W2783233751 cites W136652144 @default.
• W2783233751 cites W1523213544 @default.
• W2783233751 cites W1557884422 @default.
• W2783233751 cites W1629179716 @default.
• W2783233751 cites W1809723326 @default.
• W2783233751 cites W1973328612 @default.
• W2783233751 cites W1976977157 @default.
• W2783233751 cites W1978062256 @default.
• W2783233751 cites W1978631832 @default.
• W2783233751 cites W1982258251 @default.
• W2783233751 cites W1987453555 @default.
• W2783233751 cites W1988479401 @default.
• W2783233751 cites W1989999044 @default.
• W2783233751 cites W1994724497 @default.
• W2783233751 cites W1995445783 @default.
• W2783233751 cites W1998678889 @default.
• W2783233751 cites W1998845439 @default.
• W2783233751 cites W2003774281 @default.
• W2783233751 cites W2004611644 @default.
• W2783233751 cites W2028629022 @default.
• W2783233751 cites W2033191554 @default.
• W2783233751 cites W2040114786 @default.
• W2783233751 cites W2042968475 @default.
• W2783233751 cites W2046739471 @default.
• W2783233751 cites W2052326217 @default.
• W2783233751 cites W2061557004 @default.
• W2783233751 cites W2063382047 @default.
• W2783233751 cites W2064214500 @default.
• W2783233751 cites W2077950988 @default.
• W2783233751 cites W2080747179 @default.
• W2783233751 cites W2096439168 @default.
• W2783233751 cites W2101437995 @default.
• W2783233751 cites W2105668062 @default.
• W2783233751 cites W2121388227 @default.
• W2783233751 cites W2122341467 @default.
• W2783233751 cites W2129827453 @default.
• W2783233751 cites W2130665749 @default.
• W2783233751 cites W2130683000 @default.
• W2783233751 cites W2134967712 @default.
• W2783233751 cites W2151432607 @default.
• W2783233751 cites W2155335963 @default.
• W2783233751 cites W2155418488 @default.
• W2783233751 cites W2156251634 @default.
• W2783233751 cites W2159171427 @default.
• W2783233751 cites W2192383273 @default.
• W2783233751 cites W2339915115 @default.
• W2783233751 cites W2411982853 @default.
• W2783233751 cites W2421397230 @default.
• W2783233751 cites W2422853964 @default.
• W2783233751 cites W2444674706 @default.
• W2783233751 cites W2531291721 @default.
• W2783233751 cites W783624324 @default.
• W2783233751 doi "https://doi.org/10.1038/s41598-018-19261-w" @default.
• W2783233751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5773707" @default.
• W2783233751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29348410" @default.
• W2783233751 hasPublicationYear "2018" @default.
• W2783233751 type Work @default.
• W2783233751 sameAs 2783233751 @default.
• W2783233751 citedByCount "24" @default.
• W2783233751 countsByYear W27832337512018 @default.
• W2783233751 countsByYear W27832337512019 @default.
• W2783233751 countsByYear W27832337512020 @default.
• W2783233751 countsByYear W27832337512021 @default.
• W2783233751 countsByYear W27832337512022 @default.
• W2783233751 crossrefType "journal-article" @default.
• W2783233751 hasAuthorship W2783233751A5009470791 @default.
• W2783233751 hasAuthorship W2783233751A5013987582 @default.
• W2783233751 hasAuthorship W2783233751A5024496300 @default.
• W2783233751 hasAuthorship W2783233751A5026689823 @default.
• W2783233751 hasAuthorship W2783233751A5027080762 @default.
• W2783233751 hasAuthorship W2783233751A5049773860 @default.
• W2783233751 hasAuthorship W2783233751A5054861531 @default.
• W2783233751 hasAuthorship W2783233751A5061916566 @default.
• W2783233751 hasAuthorship W2783233751A5065740817 @default.
• W2783233751 hasAuthorship W2783233751A5077068011 @default.
• W2783233751 hasAuthorship W2783233751A5082222066 @default.
• W2783233751 hasAuthorship W2783233751A5084628898 @default.
• W2783233751 hasBestOaLocation W27832337511 @default.
• W2783233751 hasConcept C185592680 @default.
• W2783233751 hasConcept C190283241 @default.
• W2783233751 hasConcept C2776151105 @default.
• W2783233751 hasConcept C2780532915 @default.

• next