Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783238547> ?p ?o ?g. }
- W2783238547 abstract "Status epilepticus (SE) is a severe clinical manifestation of epilepsy accompanying with cognitive impairment and brain damage. Astrocyte activation occurs following seizures and plays an important role in epilepsy-induced pathological injury, including cognitive impairment. FK506, an immunosuppressant used in clinical settings to prevent allograft rejection, has been shown to exhibit neuroprotective effects in central nervous system diseases. The present study was designed to investigate the effect of FK506 on cognitive impairment in a lithium-pilocarpine-induced SE rat model. It’s found that FK506 treatment significantly increased the latency period to seizures and decreased the maximal intensity of seizures. FK506 treatment also markedly increased the surviving cells and reduced the neuron apoptosis after seizures. Meanwhile, FK506 treatment reduced the escape latency and prolonged the swimming distance in the Morris water maze test. In addition, FK506 treatment down-regulated the expression level of GFAP, a specific marker of astrocytes. In conclusion, FK506 could prevent and recover cognitive impairment by inhibiting reactive astrogliosis in pilocarpine-induced status epilepticus rats, suggesting that FK506 may be a promising agent for the treatment of epilepsy." @default.
- W2783238547 created "2018-01-26" @default.
- W2783238547 creator A5018209858 @default.
- W2783238547 creator A5027402265 @default.
- W2783238547 creator A5035701638 @default.
- W2783238547 creator A5046624008 @default.
- W2783238547 creator A5048331270 @default.
- W2783238547 creator A5077425025 @default.
- W2783238547 creator A5082255460 @default.
- W2783238547 date "2018-01-09" @default.
- W2783238547 modified "2023-10-17" @default.
- W2783238547 title "The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats" @default.
- W2783238547 cites W1262517688 @default.
- W2783238547 cites W1582404427 @default.
- W2783238547 cites W1632755291 @default.
- W2783238547 cites W1769992009 @default.
- W2783238547 cites W1776329700 @default.
- W2783238547 cites W1787988090 @default.
- W2783238547 cites W1795517153 @default.
- W2783238547 cites W1819416524 @default.
- W2783238547 cites W1906528241 @default.
- W2783238547 cites W1929027146 @default.
- W2783238547 cites W1972040317 @default.
- W2783238547 cites W1974420316 @default.
- W2783238547 cites W1981134260 @default.
- W2783238547 cites W1989639507 @default.
- W2783238547 cites W2005260297 @default.
- W2783238547 cites W2012691976 @default.
- W2783238547 cites W2018334671 @default.
- W2783238547 cites W2019260835 @default.
- W2783238547 cites W2025528474 @default.
- W2783238547 cites W2025582889 @default.
- W2783238547 cites W2033488453 @default.
- W2783238547 cites W2036697761 @default.
- W2783238547 cites W2050291088 @default.
- W2783238547 cites W2056959062 @default.
- W2783238547 cites W2057249855 @default.
- W2783238547 cites W2067102106 @default.
- W2783238547 cites W2068597324 @default.
- W2783238547 cites W2088692544 @default.
- W2783238547 cites W2091016720 @default.
- W2783238547 cites W2095931805 @default.
- W2783238547 cites W2102561151 @default.
- W2783238547 cites W2103475996 @default.
- W2783238547 cites W2103946141 @default.
- W2783238547 cites W2110734928 @default.
- W2783238547 cites W2126524125 @default.
- W2783238547 cites W2127709419 @default.
- W2783238547 cites W2162771038 @default.
- W2783238547 cites W2420123099 @default.
- W2783238547 doi "https://doi.org/10.3389/fncel.2017.00428" @default.
- W2783238547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5767224" @default.
- W2783238547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375315" @default.
- W2783238547 hasPublicationYear "2018" @default.
- W2783238547 type Work @default.
- W2783238547 sameAs 2783238547 @default.
- W2783238547 citedByCount "11" @default.
- W2783238547 countsByYear W27832385472018 @default.
- W2783238547 countsByYear W27832385472019 @default.
- W2783238547 countsByYear W27832385472020 @default.
- W2783238547 countsByYear W27832385472021 @default.
- W2783238547 countsByYear W27832385472022 @default.
- W2783238547 countsByYear W27832385472023 @default.
- W2783238547 crossrefType "journal-article" @default.
- W2783238547 hasAuthorship W2783238547A5018209858 @default.
- W2783238547 hasAuthorship W2783238547A5027402265 @default.
- W2783238547 hasAuthorship W2783238547A5035701638 @default.
- W2783238547 hasAuthorship W2783238547A5046624008 @default.
- W2783238547 hasAuthorship W2783238547A5048331270 @default.
- W2783238547 hasAuthorship W2783238547A5077425025 @default.
- W2783238547 hasAuthorship W2783238547A5082255460 @default.
- W2783238547 hasBestOaLocation W27832385471 @default.
- W2783238547 hasConcept C126322002 @default.
- W2783238547 hasConcept C128057223 @default.
- W2783238547 hasConcept C15744967 @default.
- W2783238547 hasConcept C169760540 @default.
- W2783238547 hasConcept C25498285 @default.
- W2783238547 hasConcept C2775858608 @default.
- W2783238547 hasConcept C2777204577 @default.
- W2783238547 hasConcept C2777341932 @default.
- W2783238547 hasConcept C2778186239 @default.
- W2783238547 hasConcept C2779965356 @default.
- W2783238547 hasConcept C2781161787 @default.
- W2783238547 hasConcept C2911091166 @default.
- W2783238547 hasConcept C42219234 @default.
- W2783238547 hasConcept C44752575 @default.
- W2783238547 hasConcept C529278444 @default.
- W2783238547 hasConcept C71924100 @default.
- W2783238547 hasConcept C98274493 @default.
- W2783238547 hasConceptScore W2783238547C126322002 @default.
- W2783238547 hasConceptScore W2783238547C128057223 @default.
- W2783238547 hasConceptScore W2783238547C15744967 @default.
- W2783238547 hasConceptScore W2783238547C169760540 @default.
- W2783238547 hasConceptScore W2783238547C25498285 @default.
- W2783238547 hasConceptScore W2783238547C2775858608 @default.
- W2783238547 hasConceptScore W2783238547C2777204577 @default.
- W2783238547 hasConceptScore W2783238547C2777341932 @default.
- W2783238547 hasConceptScore W2783238547C2778186239 @default.
- W2783238547 hasConceptScore W2783238547C2779965356 @default.
- W2783238547 hasConceptScore W2783238547C2781161787 @default.