FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783238692> ?p ?o ?g. }

• W2783238692 endingPage "471" @default.
• W2783238692 startingPage "464" @default.
• W2783238692 abstract "The success of targeted covalent inhibitors in the global pharmaceutical industry has led to a resurgence of covalent drug discovery. However, covalent inhibitor design for flexible binding sites remains a difficult task due to a lack of methodological development. Here, we compared covalent docking to empirical electrophile screening against the highly dynamic target K-RasG12C. While the overall hit rate of both methods was comparable, we were able to rapidly progress a docking hit to a potent irreversible covalent binder that modifies the inactive, GDP-bound state of K-RasG12C. Hydrogen-deuterium exchange mass spectrometry was used to probe the protein dynamics of compound binding to the switch-II pocket and subsequent destabilization of the nucleotide-binding region. SOS-mediated nucleotide exchange assays showed that, contrary to prior switch-II pocket inhibitors, these new compounds appear to accelerate nucleotide exchange. This study highlights the efficiency of covalent docking as a tool for the discovery of chemically novel hits against challenging targets." @default.
• W2783238692 created "2018-01-26" @default.
• W2783238692 creator A5011127417 @default.
• W2783238692 creator A5011149258 @default.
• W2783238692 creator A5029079502 @default.
• W2783238692 creator A5032002402 @default.
• W2783238692 creator A5035184259 @default.
• W2783238692 creator A5041554247 @default.
• W2783238692 creator A5044428734 @default.
• W2783238692 creator A5046372751 @default.
• W2783238692 creator A5079376363 @default.
• W2783238692 creator A5086921160 @default.
• W2783238692 date "2018-01-31" @default.
• W2783238692 modified "2023-10-17" @default.
• W2783238692 title "Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange" @default.
• W2783238692 cites W1848707615 @default.
• W2783238692 cites W1974879154 @default.
• W2783238692 cites W1979228834 @default.
• W2783238692 cites W2002368219 @default.
• W2783238692 cites W2007218072 @default.
• W2783238692 cites W2010993054 @default.
• W2783238692 cites W2012969029 @default.
• W2783238692 cites W2017738553 @default.
• W2783238692 cites W2020040806 @default.
• W2783238692 cites W2026128118 @default.
• W2783238692 cites W2037301053 @default.
• W2783238692 cites W2045865929 @default.
• W2783238692 cites W2060754823 @default.
• W2783238692 cites W2062428159 @default.
• W2783238692 cites W2066556441 @default.
• W2783238692 cites W2084485490 @default.
• W2783238692 cites W2085451507 @default.
• W2783238692 cites W2089656772 @default.
• W2783238692 cites W2089879448 @default.
• W2783238692 cites W2114869204 @default.
• W2783238692 cites W2128339707 @default.
• W2783238692 cites W2131601890 @default.
• W2783238692 cites W2138958920 @default.
• W2783238692 cites W2162478150 @default.
• W2783238692 cites W2180229411 @default.
• W2783238692 cites W2188822672 @default.
• W2783238692 cites W2233032895 @default.
• W2783238692 cites W2300615341 @default.
• W2783238692 cites W2322586343 @default.
• W2783238692 cites W2395483284 @default.
• W2783238692 cites W2507820983 @default.
• W2783238692 cites W2536408153 @default.
• W2783238692 cites W2538834948 @default.
• W2783238692 cites W2587740521 @default.
• W2783238692 cites W2615972939 @default.
• W2783238692 cites W2622009965 @default.
• W2783238692 cites W2626406025 @default.
• W2783238692 cites W2744089490 @default.
• W2783238692 doi "https://doi.org/10.1021/acs.jcim.7b00399" @default.
• W2783238692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6179444" @default.
• W2783238692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29320178" @default.
• W2783238692 hasPublicationYear "2018" @default.
• W2783238692 type Work @default.
• W2783238692 sameAs 2783238692 @default.
• W2783238692 citedByCount "42" @default.
• W2783238692 countsByYear W27832386922018 @default.
• W2783238692 countsByYear W27832386922019 @default.
• W2783238692 countsByYear W27832386922020 @default.
• W2783238692 countsByYear W27832386922021 @default.
• W2783238692 countsByYear W27832386922022 @default.
• W2783238692 countsByYear W27832386922023 @default.
• W2783238692 crossrefType "journal-article" @default.
• W2783238692 hasAuthorship W2783238692A5011127417 @default.
• W2783238692 hasAuthorship W2783238692A5011149258 @default.
• W2783238692 hasAuthorship W2783238692A5029079502 @default.
• W2783238692 hasAuthorship W2783238692A5032002402 @default.
• W2783238692 hasAuthorship W2783238692A5035184259 @default.
• W2783238692 hasAuthorship W2783238692A5041554247 @default.
• W2783238692 hasAuthorship W2783238692A5044428734 @default.
• W2783238692 hasAuthorship W2783238692A5046372751 @default.
• W2783238692 hasAuthorship W2783238692A5079376363 @default.
• W2783238692 hasAuthorship W2783238692A5086921160 @default.
• W2783238692 hasBestOaLocation W27832386922 @default.
• W2783238692 hasConcept C104317684 @default.
• W2783238692 hasConcept C112887158 @default.
• W2783238692 hasConcept C159110408 @default.
• W2783238692 hasConcept C178790620 @default.
• W2783238692 hasConcept C180577832 @default.
• W2783238692 hasConcept C185592680 @default.
• W2783238692 hasConcept C21951064 @default.
• W2783238692 hasConcept C3018522384 @default.
• W2783238692 hasConcept C32909587 @default.
• W2783238692 hasConcept C41685203 @default.
• W2783238692 hasConcept C512185932 @default.
• W2783238692 hasConcept C55493867 @default.
• W2783238692 hasConcept C71924100 @default.
• W2783238692 hasConcept C74187038 @default.
• W2783238692 hasConceptScore W2783238692C104317684 @default.
• W2783238692 hasConceptScore W2783238692C112887158 @default.
• W2783238692 hasConceptScore W2783238692C159110408 @default.
• W2783238692 hasConceptScore W2783238692C178790620 @default.
• W2783238692 hasConceptScore W2783238692C180577832 @default.
• W2783238692 hasConceptScore W2783238692C185592680 @default.

• next