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• W2783244104 abstract "Ultrasound (US) can noninvasively activate intact brain circuits, making it a promising neuromodulation technique. However, little is known about the underlying mechanism. Here, we apply transcranial US and perform brain mapping studies in guinea pigs using extracellular electrophysiology. We find that US elicits extensive activation across cortical and subcortical brain regions. However, transection of the auditory nerves or removal of cochlear fluids eliminates the US-induced activity, revealing an indirect auditory mechanism for US neural activation. Our findings indicate that US activates the ascending auditory system through a cochlear pathway, which can activate other non-auditory regions through cross-modal projections. This cochlear pathway mechanism challenges the idea that US can directly activate neurons in the intact brain, suggesting that future US stimulation studies will need to control for this effect to reach reliable conclusions." @default.
• W2783244104 created "2018-01-26" @default.
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• W2783244104 date "2018-06-01" @default.
• W2783244104 modified "2023-10-11" @default.
• W2783244104 title "Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway" @default.
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• W2783244104 doi "https://doi.org/10.1016/j.neuron.2018.04.036" @default.
• W2783244104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30138592" @default.
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