FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783246146> ?p ?o ?g. }

• W2783246146 abstract "Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride through enhancing its rate of release from tablet formulation prepared from either technique. Methods: Drug release from TSDads or SA tablets with different added excipients was explored. Scanning electron microscopy (SEM) and effect of compression on dissolution were illustrated. Pharmacodynamic evaluation was performed on optimized tablets. Results: TSDads & SA tablets with Cross Povidone showed least disintegration times of 1.48 and 0.5 min. respectively. Kinetics of drug release recorded least half-lives (54.13 and 59.83min for both techniques respectively). Cross section in tablets displayed an organized interconnected matrix under SEM, accounting for the rapid access of dissolution media to the tablet core. Components of tablets filled into capsules showed a similar release profile to that of tablets after compression as indicated by similarity factor. The onset time of maximum reduction in blood glucose in male albino rabbits was hastened to 2h instead of 3h for commercial tablets. Conclusion: After optimization of tablet excipients that interacted differently with respect to their effect on drug release, we could conclude that both amorphisation and spheronization were equally successful in promoting in vitro dissolution enhancement as well as providing a more rapid onset time for drug action in vivo." @default.
• W2783246146 created "2018-01-26" @default.
• W2783246146 creator A5006867217 @default.
• W2783246146 creator A5021602801 @default.
• W2783246146 creator A5071831611 @default.
• W2783246146 creator A5078968799 @default.
• W2783246146 date "2017-12-31" @default.
• W2783246146 modified "2023-10-06" @default.
• W2783246146 title "The Impact of Amorphisation and Spheronization Techniques on the Improved in Vitro & in Vivo Performance of Glimepiride Tablets" @default.
• W2783246146 cites W1195955210 @default.
• W2783246146 cites W1965316343 @default.
• W2783246146 cites W1970084786 @default.
• W2783246146 cites W1976606669 @default.
• W2783246146 cites W1978080874 @default.
• W2783246146 cites W1980033294 @default.
• W2783246146 cites W1983521939 @default.
• W2783246146 cites W1986636886 @default.
• W2783246146 cites W1999527241 @default.
• W2783246146 cites W2000738099 @default.
• W2783246146 cites W2000839017 @default.
• W2783246146 cites W2001577100 @default.
• W2783246146 cites W2005610781 @default.
• W2783246146 cites W2015404896 @default.
• W2783246146 cites W2021849622 @default.
• W2783246146 cites W2027914820 @default.
• W2783246146 cites W2029720457 @default.
• W2783246146 cites W2037106970 @default.
• W2783246146 cites W2043681998 @default.
• W2783246146 cites W2044497904 @default.
• W2783246146 cites W2044628190 @default.
• W2783246146 cites W2046080776 @default.
• W2783246146 cites W2046219127 @default.
• W2783246146 cites W2054757015 @default.
• W2783246146 cites W2081026009 @default.
• W2783246146 cites W2081497149 @default.
• W2783246146 cites W2087333398 @default.
• W2783246146 cites W2088868031 @default.
• W2783246146 cites W2089708485 @default.
• W2783246146 cites W2092527798 @default.
• W2783246146 cites W2101199741 @default.
• W2783246146 cites W2102301444 @default.
• W2783246146 cites W2110215575 @default.
• W2783246146 cites W2136522781 @default.
• W2783246146 cites W2141566507 @default.
• W2783246146 cites W2141569620 @default.
• W2783246146 cites W2145037190 @default.
• W2783246146 cites W2151678885 @default.
• W2783246146 cites W2155435315 @default.
• W2783246146 cites W2165249259 @default.
• W2783246146 cites W2171825230 @default.
• W2783246146 cites W2320617100 @default.
• W2783246146 cites W2322282582 @default.
• W2783246146 cites W2462065949 @default.
• W2783246146 doi "https://doi.org/10.15171/apb.2017.067" @default.
• W2783246146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5788210" @default.
• W2783246146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29399545" @default.
• W2783246146 hasPublicationYear "2017" @default.
• W2783246146 type Work @default.
• W2783246146 sameAs 2783246146 @default.
• W2783246146 citedByCount "2" @default.
• W2783246146 countsByYear W27832461462019 @default.
• W2783246146 countsByYear W27832461462022 @default.
• W2783246146 crossrefType "journal-article" @default.
• W2783246146 hasAuthorship W2783246146A5006867217 @default.
• W2783246146 hasAuthorship W2783246146A5021602801 @default.
• W2783246146 hasAuthorship W2783246146A5071831611 @default.
• W2783246146 hasAuthorship W2783246146A5078968799 @default.
• W2783246146 hasBestOaLocation W27832461461 @default.
• W2783246146 hasConcept C126322002 @default.
• W2783246146 hasConcept C136229726 @default.
• W2783246146 hasConcept C147789679 @default.
• W2783246146 hasConcept C150903083 @default.
• W2783246146 hasConcept C159985019 @default.
• W2783246146 hasConcept C185592680 @default.
• W2783246146 hasConcept C192562407 @default.
• W2783246146 hasConcept C207001950 @default.
• W2783246146 hasConcept C26771246 @default.
• W2783246146 hasConcept C2776307423 @default.
• W2783246146 hasConcept C2779306644 @default.
• W2783246146 hasConcept C2780323712 @default.
• W2783246146 hasConcept C43617362 @default.
• W2783246146 hasConcept C71924100 @default.
• W2783246146 hasConcept C77281830 @default.
• W2783246146 hasConcept C86803240 @default.
• W2783246146 hasConcept C88380143 @default.
• W2783246146 hasConcept C98274493 @default.
• W2783246146 hasConceptScore W2783246146C126322002 @default.
• W2783246146 hasConceptScore W2783246146C136229726 @default.
• W2783246146 hasConceptScore W2783246146C147789679 @default.
• W2783246146 hasConceptScore W2783246146C150903083 @default.
• W2783246146 hasConceptScore W2783246146C159985019 @default.
• W2783246146 hasConceptScore W2783246146C185592680 @default.
• W2783246146 hasConceptScore W2783246146C192562407 @default.
• W2783246146 hasConceptScore W2783246146C207001950 @default.
• W2783246146 hasConceptScore W2783246146C26771246 @default.
• W2783246146 hasConceptScore W2783246146C2776307423 @default.
• W2783246146 hasConceptScore W2783246146C2779306644 @default.
• W2783246146 hasConceptScore W2783246146C2780323712 @default.
• W2783246146 hasConceptScore W2783246146C43617362 @default.
• W2783246146 hasConceptScore W2783246146C71924100 @default.

• next