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• W2783246934 abstract "Programmed death-ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment, and PD-L1 blockade therapy has shown unprecedented durable responses in several clinical studies. Although higher expression of PD-L1 on tumor cells is associated with a better immune response after Ab blockade, some PD-L1-negative patients also respond to this therapy. In the current study, we explored whether PD-L1 on tumor or host cells was essential for anti-PD-L1-mediated therapy in 2 different murine tumor models. Using real-time imaging in whole tumor tissues, we found that anti-PD-L1 Ab accumulates in tumor tissues, regardless of the status of PD-L1 expression on tumor cells. We further observed that, while PD-L1 on tumor cells was largely dispensable for the response to checkpoint blockade, PD-L1 in host myeloid cells was essential for this response. Additionally, PD-L1 signaling in defined antigen-presenting cells (APCs) negatively regulated and inhibited T cell activation. PD-L1 blockade inside tumors was not sufficient to mediate regression, as limiting T cell trafficking reduced the efficacy of the blockade. Together, these findings demonstrate that PD-L1 expressed in APCs, rather than on tumor cells, plays an essential role in checkpoint blockade therapy, providing an insight into the mechanisms of this therapy." @default.
• W2783246934 created "2018-01-26" @default.
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• W2783246934 date "2018-01-16" @default.
• W2783246934 modified "2023-10-16" @default.
• W2783246934 title "PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression" @default.
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• W2783246934 doi "https://doi.org/10.1172/jci96061" @default.
• W2783246934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5785245" @default.
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• W2783246934 hasPublicationYear "2018" @default.
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