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- W2783248069 abstract "Glycans are inherently heterogeneous, yet glycosylation is essential in eukaryotes and glycans show characteristic cell type dependent distributions. Using an immortalized human mesenchymal stromal cell (MSC) line model we show that both N- and O-glycan processing in the Golgi functionally modulate early steps of osteogenic differentiation. Inhibiting O-glycan processing in the Golgi prior to the start of osteogenesis inhibited the mineralization capacity of the formed osteoblasts three weeks later. In contrast, inhibition of N-glycan processing in MSCs altered differentiation to enhance mineralization capacity of the osteoblasts. The effect of N-glycans on MSC differentiation was mediated by the phosphoinositide-3-kinase (PI3K)/Akt pathway through reduced Akt phosphorylation. Interestingly, by inhibiting PI3K during the first two days of osteogenesis we were able to phenocopy the effect of inhibiting N-glycan processing. Thus modulating the functional outcome of differentiation through glycan processing provides another layer of regulation. Glycan processing can thereby offer a novel set of targets for many therapeutically attractive processes." @default.
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- W2783248069 date "2018-01-01" @default.
- W2783248069 modified "2023-09-26" @default.
- W2783248069 title "Glycans modify mesenchymal stem cell differentiation to impact the function of resulting osteoblasts" @default.
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- W2783248069 doi "https://doi.org/10.1242/jcs.209452" @default.
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