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- W2783251220 abstract "Purpose of review This review summarizes the hallmark developments in induction chemotherapy for acute myeloid leukaemia and further describes future directions in its evolution. Recent findings We describe the origin of induction chemotherapy. We also describe notable modifications and adjustments to 7+3 induction chemotherapy since its development. Finally, we describe new efforts to modify and add new agents to induction therapy, including ‘7+3 Plus’ combinations. Summary Induction chemotherapy remains the standard of care for the majority of patients with acute myeloid leukaemia. However, its success is limited in a subset of patients by toxicity, failure to achieve remission and potential for subsequent relapse. Novel agents such as mutant fms like tyrosine kinase 3 inhibitors, mutant isocitrate dehydrogenase inhibitors, CD33-antibody drug conjugates and liposomal formulations have demonstrated significant potential as modifications to traditional induction chemotherapy." @default.
- W2783251220 created "2018-01-26" @default.
- W2783251220 creator A5010057352 @default.
- W2783251220 creator A5016458162 @default.
- W2783251220 date "2018-03-01" @default.
- W2783251220 modified "2023-10-18" @default.
- W2783251220 title "Induction chemotherapy in acute myeloid leukaemia" @default.
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- W2783251220 doi "https://doi.org/10.1097/moh.0000000000000407" @default.
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