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- W2783257305 abstract "The present studies are aimed for overcoming these commonproblems by introducing solid dispersion technology using various carriersand thus improve its dissolution characteristics. This study deals with an effective anti-inflammatory drug. Indomethacin which is poorly soluble inwater where the dissolution rate is limited. Indomethacin solid dispersions were prepared using carriers such asβ-CD and HPβ-CD. In this present study the solid dispersions were preparedby Co-evaporation for both the polymers and kneading method for β-CD andHPβ-CD.The solid dispersions prepared were found to be free flowing powders.In TLC studies single spots appeared for pure drug and solid dispersionsshows that there was no interaction between the drug and the carrier used.The IR spectra obtained for the solid dispersions were matching withreference standards. This indicates that the drug was pure and the spectraobtained from solid dispersions were matching with the original spectra. Nocharacteristic peaks were disappeared or newly appeared which confirmedthe absence of any chemical interaction between the drug and the carrier.X-Ray diffraction studies revealed that the crystalline nature ofIndomethacin in pure form was reduced in the solid dispersions and this mightbe the reason for increased dissolution rate. DSC thermogram showed no interaction between drug and polymer. Italso indicates the amorphous character of solid dispersion.Results of dissolution studies showed rapid and fast dissolution ofIndomethacin from all solid dispersions when compared with physical mixtureand pure drug. The dissolution from all dispersions showed first orderkinetics. Among two Cyclodextrins, HPβ-CD gave the faster dissolution." @default.
- W2783257305 created "2018-01-26" @default.
- W2783257305 creator A5013394386 @default.
- W2783257305 date "2009-03-01" @default.
- W2783257305 modified "2023-09-27" @default.
- W2783257305 title "Preparation, Characterization and Evaluation of Indomethacin Solid Dispersions" @default.
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- W2783257305 hasPublicationYear "2009" @default.
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