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- W2783257670 abstract "Colorectal carcinoma is the second leading cancer killer and third mostcommon cancer throughout the world. Capecitabine is a new drug for orallyadministered and widely used for the treatment of colorectal cancer. The firstpass metabolism of capecitabine is a problem in achieving bioavailibility.Development of colon targeting microspheres will be the promising technique toavoid first pass metabolism and to achieve the desired bioavailibility profile. The present study is focused on development of capecitabineloaded alginate microspheres and filled in capsules followed by Eudragit-S-100coating for targeting to colon region. The results suggested that drug, 4% sodiumalginate 1:2 ratio with 2% cross linking agent (FA2) was found to be the bestformulation and showed 87.1% release in 2hrs with 79.7% entrapment. So theformulation is selected for further coating with Eudragit-S-100 for targeting tocolon region. The coated capsules release studies shows no evidence of drugrelease for up to 6hrs. It is evident that the GI emptying time can be bypassed bythe coated capsules the drug release of 51% at the end of 10hrs from coatedcapsules. Suggests the Eudragit-S-100 coating only degrading in colon pH. Theprepared formulation can be further evaluated in vivo for correlating in vitro studyresults. The prepared microspheres is a promising colon targeted delivery devicefor achieving better kinetic profile with improved bioavailibility." @default.
- W2783257670 created "2018-01-26" @default.
- W2783257670 creator A5015746753 @default.
- W2783257670 date "2009-03-01" @default.
- W2783257670 modified "2023-09-27" @default.
- W2783257670 title "Targeted Drug Delivery of Capecitabine Microspheres for Colorectal Cancer" @default.
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