FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783262196> ?p ?o ?g. }

• W2783262196 endingPage "60" @default.
• W2783262196 startingPage "52" @default.
• W2783262196 abstract "Abstract Aims Tryptophan 2,3‐dioxygenase ( TDO 2) is an initial rate‐limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) metabolism. The Trp‐degrading enzymes, TDO 2 and indoleamine 2,3‐dioxygenase, are activated by stress and/or inflammation. Dysregulation of Trp metabolism, which causes shifts in the balance between Kyn and serotonin (5‐ HT ) pathways, is associated with psychiatric and neurological disorders. In genetic studies, single‐nucleotide polymorphisms in the TDO 2 gene were shown to be involved in psychiatric disorders, such as schizophrenia and depression. It has been reported that targeted deletion of the Tdo2 gene in mice resulted in reduced anxiety‐like behavior, enhanced exploratory activity and cognitive performance, and increased levels of Trp and 5‐ HT in the hippocampus and midbrain. However, the effect of Tdo2 gene deletion on behavioral phenotypes has not yet been investigated extensively. Materials & Methods We conducted tests to further examine the behavioral effects of knockout ( KO ) of Tdo2 in mice. Results Deletion of Tdo2 resulted in seemingly lower anxiety‐like behavior, higher locomotor activity, and abnormal gait pattern in mice, though none of them reached study‐wide statistical significance. Tdo2 deficiency had no significant effects on other behaviors, such as prepulse inhibition, and depression‐like and social behaviors. Discussion and Conclusion He lack of clear phenotypes in Tdo2 KO mice in this study might be due to the absence of stress and inflammatory conditions, which could induce expression of Tdo2 m RNA . Further studies are necessary to elucidate the roles of Tdo2 in behavioral phenotypes related to psychiatric disorders." @default.
• W2783262196 created "2018-01-26" @default.
• W2783262196 creator A5004444803 @default.
• W2783262196 creator A5029912301 @default.
• W2783262196 creator A5058103958 @default.
• W2783262196 creator A5086676643 @default.
• W2783262196 date "2018-03-15" @default.
• W2783262196 modified "2023-09-23" @default.
• W2783262196 title "Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (<i>Tdo2</i> ) knockout mice" @default.
• W2783262196 cites W1529722613 @default.
• W2783262196 cites W1789263674 @default.
• W2783262196 cites W1963756597 @default.
• W2783262196 cites W1970629813 @default.
• W2783262196 cites W1976924995 @default.
• W2783262196 cites W1977966461 @default.
• W2783262196 cites W1978830885 @default.
• W2783262196 cites W198061727 @default.
• W2783262196 cites W1990393276 @default.
• W2783262196 cites W2021620079 @default.
• W2783262196 cites W2025293038 @default.
• W2783262196 cites W2025329986 @default.
• W2783262196 cites W2040856053 @default.
• W2783262196 cites W2044559869 @default.
• W2783262196 cites W2050792638 @default.
• W2783262196 cites W2053486952 @default.
• W2783262196 cites W2060050678 @default.
• W2783262196 cites W2064981193 @default.
• W2783262196 cites W2085301448 @default.
• W2783262196 cites W2087250343 @default.
• W2783262196 cites W2090117293 @default.
• W2783262196 cites W2090470620 @default.
• W2783262196 cites W2101445441 @default.
• W2783262196 cites W2109091674 @default.
• W2783262196 cites W2109497244 @default.
• W2783262196 cites W2120257505 @default.
• W2783262196 cites W2123128031 @default.
• W2783262196 cites W2123485468 @default.
• W2783262196 cites W2126795224 @default.
• W2783262196 cites W2147819824 @default.
• W2783262196 cites W2148239264 @default.
• W2783262196 cites W2263774645 @default.
• W2783262196 cites W2345920049 @default.
• W2783262196 cites W2397045879 @default.
• W2783262196 cites W2429603639 @default.
• W2783262196 cites W2508775775 @default.
• W2783262196 cites W2531113275 @default.
• W2783262196 cites W2783262196 @default.
• W2783262196 doi "https://doi.org/10.1002/npr2.12006" @default.
• W2783262196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7292271" @default.
• W2783262196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30106261" @default.
• W2783262196 hasPublicationYear "2018" @default.
• W2783262196 type Work @default.
• W2783262196 sameAs 2783262196 @default.
• W2783262196 citedByCount "17" @default.
• W2783262196 countsByYear W27832621962018 @default.
• W2783262196 countsByYear W27832621962019 @default.
• W2783262196 countsByYear W27832621962020 @default.
• W2783262196 countsByYear W27832621962021 @default.
• W2783262196 countsByYear W27832621962022 @default.
• W2783262196 countsByYear W27832621962023 @default.
• W2783262196 crossrefType "journal-article" @default.
• W2783262196 hasAuthorship W2783262196A5004444803 @default.
• W2783262196 hasAuthorship W2783262196A5029912301 @default.
• W2783262196 hasAuthorship W2783262196A5058103958 @default.
• W2783262196 hasAuthorship W2783262196A5086676643 @default.
• W2783262196 hasBestOaLocation W27832621961 @default.
• W2783262196 hasConcept C104317684 @default.
• W2783262196 hasConcept C118552586 @default.
• W2783262196 hasConcept C127716648 @default.
• W2783262196 hasConcept C141421786 @default.
• W2783262196 hasConcept C15744967 @default.
• W2783262196 hasConcept C182704531 @default.
• W2783262196 hasConcept C2776412080 @default.
• W2783262196 hasConcept C2776706248 @default.
• W2783262196 hasConcept C2776710720 @default.
• W2783262196 hasConcept C2777503454 @default.
• W2783262196 hasConcept C515207424 @default.
• W2783262196 hasConcept C54355233 @default.
• W2783262196 hasConcept C86803240 @default.
• W2783262196 hasConceptScore W2783262196C104317684 @default.
• W2783262196 hasConceptScore W2783262196C118552586 @default.
• W2783262196 hasConceptScore W2783262196C127716648 @default.
• W2783262196 hasConceptScore W2783262196C141421786 @default.
• W2783262196 hasConceptScore W2783262196C15744967 @default.
• W2783262196 hasConceptScore W2783262196C182704531 @default.
• W2783262196 hasConceptScore W2783262196C2776412080 @default.
• W2783262196 hasConceptScore W2783262196C2776706248 @default.
• W2783262196 hasConceptScore W2783262196C2776710720 @default.
• W2783262196 hasConceptScore W2783262196C2777503454 @default.
• W2783262196 hasConceptScore W2783262196C515207424 @default.
• W2783262196 hasConceptScore W2783262196C54355233 @default.
• W2783262196 hasConceptScore W2783262196C86803240 @default.
• W2783262196 hasFunder F4320320912 @default.
• W2783262196 hasIssue "2" @default.
• W2783262196 hasLocation W27832621961 @default.
• W2783262196 hasLocation W27832621962 @default.
• W2783262196 hasLocation W27832621963 @default.
• W2783262196 hasLocation W27832621964 @default.

• next