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- W2783266677 abstract "Apoptotic death of cardiac myocytes is associated with ischemic heart disease and chemotherapy-induced cardiomyopathy. Chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) is highly expressed in the heart. However, its specific role in ischemic cardiomyopathy is not fully understood. Here, we demonstrated that CRTH2 disruption markedly improved cardiac recovery in mice postmyocardial infarction and doxorubicin challenge by suppressing cardiomyocyte apoptosis. Mechanistically, CRTH2 activation specifically facilitated endoplasmic reticulum (ER) stress-induced cardiomyocyte apoptosis via caspase-12-dependent pathway. Blockage of m-calpain prevented CRTH2-mediated cardiomyocyte apoptosis under ER stress by suppressing caspase-12 activity. CRTH2 was coupled with Gαq to elicit intracellular Ca2+ flux and activated m-calpain/caspase-12 cascade in cardiomyocytes. Knockdown of caspase-4, an alternative to caspase-12 in humans, markedly alleviated CRHT2 activation-induced apoptosis in human cardiomyocyte response to anoxia. Our findings revealed an unexpected role of CRTH2 in promoting ER stress-induced cardiomyocyte apoptosis, suggesting that CRTH2 inhibition has therapeutic potential for ischemic cardiomyopathy." @default.
- W2783266677 created "2018-01-26" @default.
- W2783266677 creator A5001078737 @default.
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- W2783266677 creator A5082174447 @default.
- W2783266677 date "2018-01-15" @default.
- W2783266677 modified "2023-10-18" @default.
- W2783266677 title "CRTH2 promotes endoplasmic reticulum stress‐induced cardiomyocyte apoptosis through m‐calpain" @default.
- W2783266677 cites W1484399489 @default.
- W2783266677 cites W1540517667 @default.
- W2783266677 cites W1646908419 @default.
- W2783266677 cites W1964272444 @default.
- W2783266677 cites W1965185652 @default.
- W2783266677 cites W1974643497 @default.
- W2783266677 cites W1974869420 @default.
- W2783266677 cites W1976129366 @default.
- W2783266677 cites W1985339713 @default.
- W2783266677 cites W1987593270 @default.
- W2783266677 cites W1987710524 @default.
- W2783266677 cites W1989117215 @default.
- W2783266677 cites W1990921906 @default.
- W2783266677 cites W1991642980 @default.
- W2783266677 cites W2001330852 @default.
- W2783266677 cites W2002439304 @default.
- W2783266677 cites W2004736524 @default.
- W2783266677 cites W2005866728 @default.
- W2783266677 cites W2017605264 @default.
- W2783266677 cites W2019922945 @default.
- W2783266677 cites W2024050471 @default.
- W2783266677 cites W2030982691 @default.
- W2783266677 cites W2034213169 @default.
- W2783266677 cites W2035006418 @default.
- W2783266677 cites W2050359676 @default.
- W2783266677 cites W2054478275 @default.
- W2783266677 cites W2055545648 @default.
- W2783266677 cites W2056982291 @default.
- W2783266677 cites W2057477562 @default.
- W2783266677 cites W2060935391 @default.
- W2783266677 cites W2064752763 @default.
- W2783266677 cites W2073651858 @default.
- W2783266677 cites W2080514250 @default.
- W2783266677 cites W2081004896 @default.
- W2783266677 cites W2086296564 @default.
- W2783266677 cites W2087788651 @default.
- W2783266677 cites W2088749722 @default.
- W2783266677 cites W2090236425 @default.
- W2783266677 cites W2091845940 @default.
- W2783266677 cites W2092512238 @default.
- W2783266677 cites W2095607155 @default.
- W2783266677 cites W2108862261 @default.
- W2783266677 cites W2109762329 @default.
- W2783266677 cites W2110412870 @default.
- W2783266677 cites W2118124035 @default.
- W2783266677 cites W2123280495 @default.
- W2783266677 cites W2133190342 @default.
- W2783266677 cites W2136666117 @default.
- W2783266677 cites W2138349718 @default.
- W2783266677 cites W2140061120 @default.
- W2783266677 cites W2144135883 @default.
- W2783266677 cites W2147145830 @default.
- W2783266677 cites W2152522654 @default.
- W2783266677 cites W2156797817 @default.
- W2783266677 cites W2159923131 @default.
- W2783266677 cites W2163149796 @default.
- W2783266677 cites W2166893697 @default.
- W2783266677 cites W2167202160 @default.
- W2783266677 cites W2167711201 @default.
- W2783266677 cites W2168809313 @default.
- W2783266677 cites W2170015173 @default.
- W2783266677 cites W2171068341 @default.
- W2783266677 cites W2192080449 @default.
- W2783266677 cites W2231291760 @default.
- W2783266677 cites W2256408507 @default.
- W2783266677 cites W2259804540 @default.
- W2783266677 cites W2262375366 @default.
- W2783266677 cites W2266388615 @default.
- W2783266677 cites W2296573951 @default.
- W2783266677 cites W2301761598 @default.
- W2783266677 cites W2471862159 @default.
- W2783266677 cites W2477792781 @default.
- W2783266677 cites W2519255701 @default.
- W2783266677 cites W2528404628 @default.
- W2783266677 cites W2543741457 @default.
- W2783266677 cites W2550827765 @default.
- W2783266677 cites W2570925328 @default.
- W2783266677 cites W2580792129 @default.
- W2783266677 cites W2584151380 @default.