FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783270596> ?p ?o ?g. }

• W2783270596 abstract "Type 2 diabetes mellitus (DM) is a common metabolic disorder predisposing to diabetic cardiomyopathy and atherosclerotic cardiovascular disease (CVD), which could lead to heart failure through a variety of mechanisms, including myocardial infarction and chronic pressure overload. Pathogenetic mechanisms, mainly linked to hyperglycemia and chronic sustained hyperinsulinemia, include changes in metabolic profiles, intracellular signaling pathways, energy production, redox status, increased susceptibility to ischemia, and extracellular matrix remodeling. The close relationship between type 2 DM and CVD has led to the common soil hypothesis, postulating that both conditions share common genetic and environmental factors influencing this association. However, although the common risk factors of both CVD and type 2 DM, such as obesity, insulin resistance, dyslipidemia, inflammation and thrombophilia, can be identified in the majority of affected patients, less is known about how these factors influence both conditions, so that efforts are still needed for a more comprehensive understanding of this relationship. The genetic, epigenetic, and environmental backgrounds of both type 2 DM and CVD have been more recently studied and updated. However, the underlying pathogenetic mechanisms have seldom been investigated within the broader shared background, but rather studied in the specific context of type 2 DM or CVD, separately. As the precise pathophysiological links between type 2 DM and CVD are not entirely understood and many aspects still require elucidation, an integrated description of the genetic, epigenetic, and environmental influences involved in the concomitant development of both diseases is of paramount importance to shed new light on the interlinks between type 2 DM and CVD. This review addresses the current knowledge of overlapping genetic and epigenetic aspects in type 2 DM and CVD, including microRNAs (miRNAs) and long non-coding RNAs (lnc-RNAs), whose abnormal regulation has been implicated in both disease conditions, either etiologically or as cause for their progression. Understanding the links between these disorders may help to drive future research towards an integrated pathophysiological approach and to provide future directions in the field." @default.
• W2783270596 created "2018-01-26" @default.
• W2783270596 creator A5039638412 @default.
• W2783270596 creator A5051882371 @default.
• W2783270596 creator A5053892251 @default.
• W2783270596 creator A5053969558 @default.
• W2783270596 creator A5068281952 @default.
• W2783270596 creator A5076502823 @default.
• W2783270596 date "2018-01-17" @default.
• W2783270596 modified "2023-10-16" @default.
• W2783270596 title "Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links" @default.
• W2783270596 cites W11598776 @default.
• W2783270596 cites W1480785638 @default.
• W2783270596 cites W1489213426 @default.
• W2783270596 cites W1501953439 @default.
• W2783270596 cites W1517455532 @default.
• W2783270596 cites W1524496092 @default.
• W2783270596 cites W1531396004 @default.
• W2783270596 cites W1549420169 @default.
• W2783270596 cites W1596627994 @default.
• W2783270596 cites W1671079142 @default.
• W2783270596 cites W1863336415 @default.
• W2783270596 cites W1932916050 @default.
• W2783270596 cites W1944558458 @default.
• W2783270596 cites W1963854785 @default.
• W2783270596 cites W1965141016 @default.
• W2783270596 cites W1966884669 @default.
• W2783270596 cites W1967607974 @default.
• W2783270596 cites W1969143891 @default.
• W2783270596 cites W1969178186 @default.
• W2783270596 cites W1971130596 @default.
• W2783270596 cites W1972104572 @default.
• W2783270596 cites W1973519653 @default.
• W2783270596 cites W1976157410 @default.
• W2783270596 cites W1978208518 @default.
• W2783270596 cites W1979953062 @default.
• W2783270596 cites W1982481096 @default.
• W2783270596 cites W1983515210 @default.
• W2783270596 cites W1985388914 @default.
• W2783270596 cites W1986443233 @default.
• W2783270596 cites W1987684274 @default.
• W2783270596 cites W1988007795 @default.
• W2783270596 cites W1992518836 @default.
• W2783270596 cites W1994605156 @default.
• W2783270596 cites W1995085194 @default.
• W2783270596 cites W1996630410 @default.
• W2783270596 cites W2001206276 @default.
• W2783270596 cites W2002404684 @default.
• W2783270596 cites W2004368757 @default.
• W2783270596 cites W2013035559 @default.
• W2783270596 cites W2014663082 @default.
• W2783270596 cites W2016256541 @default.
• W2783270596 cites W2016726091 @default.
• W2783270596 cites W2016953051 @default.
• W2783270596 cites W2018905522 @default.
• W2783270596 cites W2019559882 @default.
• W2783270596 cites W2020267609 @default.
• W2783270596 cites W2020860086 @default.
• W2783270596 cites W2021196139 @default.
• W2783270596 cites W2023531846 @default.
• W2783270596 cites W2025143098 @default.
• W2783270596 cites W2027065592 @default.
• W2783270596 cites W2027218679 @default.
• W2783270596 cites W2027670788 @default.
• W2783270596 cites W2028555804 @default.
• W2783270596 cites W2032183472 @default.
• W2783270596 cites W2032514894 @default.
• W2783270596 cites W2036198235 @default.
• W2783270596 cites W2037170170 @default.
• W2783270596 cites W2043355615 @default.
• W2783270596 cites W2044270602 @default.
• W2783270596 cites W2047040773 @default.
• W2783270596 cites W2048537883 @default.
• W2783270596 cites W2048755332 @default.
• W2783270596 cites W2049513468 @default.
• W2783270596 cites W2050739627 @default.
• W2783270596 cites W2050778362 @default.
• W2783270596 cites W2054558116 @default.
• W2783270596 cites W2056353951 @default.
• W2783270596 cites W2056746675 @default.
• W2783270596 cites W2057835664 @default.
• W2783270596 cites W2060747387 @default.
• W2783270596 cites W2069616685 @default.
• W2783270596 cites W2070218696 @default.
• W2783270596 cites W2070692648 @default.
• W2783270596 cites W2070777085 @default.
• W2783270596 cites W2071271349 @default.
• W2783270596 cites W2071944562 @default.
• W2783270596 cites W2072470895 @default.
• W2783270596 cites W2075481792 @default.
• W2783270596 cites W2075604783 @default.
• W2783270596 cites W2076873046 @default.
• W2783270596 cites W2078220620 @default.
• W2783270596 cites W2078781443 @default.
• W2783270596 cites W2078784990 @default.
• W2783270596 cites W2080696342 @default.
• W2783270596 cites W2081742737 @default.
• W2783270596 cites W2081807421 @default.
• W2783270596 cites W2082122713 @default.
• W2783270596 cites W2082957297 @default.

• next