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- W2783272125 abstract "Additional Supporting Information may be found in the online version of this article at the publisher's website. Supplemental Figure. Distribution and morphology of Lewy-related pathology in olfactory bulb (a-c). Three distribution patterns were detected; (a) only in anterior olfactory nucleus; (b) only in peripheral regions of olfactory bulb, including inner plexiform and mitral cell layers; (c) in both regions. Representative morphological features in Lewy-related pathology in olfactory bulb (d-f). Hyaline-type Lewy bodies (d) were infrequent compared with cortical-type Lewy bodies (e). Lewy neurites, dots, and threads were frequent, and some spheroids were also detected (arrow). Scale bar = 20 µm (a-f). Supplemental Table. Distribution of Lewy-related pathology and olfactory tau pathology of cases with olfactory bulb involvement. These tabulated 21 cases had not been recognized as having Lewy-related pathology before olfactory bulb screening. Numbers represent scores (based on a 5-point scale) for the density and distribution of Lewy-related pathology: 0 = no Lewy-related pathology; 1 = rare Lewy bodies or Lewy neurites; 2 = more than 1 Lewy body per field and sparse Lewy neurites; 3 = 4 or more Lewy bodies and scattered Lewy neurites per field; 4 = numerous Lewy bodies and Lewy neurites. Note that Lewy-related pathology was restricted to olfactory bulb in 6 cases. The severity of olfactory tau pathology (ie, NFT and neuropil thread) was scored on a 4-point semiquantitative scale (0 = none, 1 = sparse, 2 = moderate, 3 = frequent). AON, Lewy-related pathology restricted to anterior olfactory nucleus; Peri, Lewy-related pathology restricted to olfactory bulb periphery; AON + Peri, Lewy-related pathology found in both anterior olfactory nucleus and olfactory bulb periphery; Amy, amygdala; DMN, dorsal motor nucleus of vagus; nbM, nucleus of Meynert basalis; LC, locus coeruleus; SN, substantia nigra; Beach, unified LBD staging system29; AD, Alzheimer's disease; CBD, corticobasal degeneration; FTLD-TDP, frontotemporal lobar degeneration with TDP-43 inclusions; MSA, multiple system atrophy; normal, neurologically normal; PA, pathological aging; PART, primary age-related tauopathy; PSP, progressive supranuclear palsy; CVD, cerebrovascular disease. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W2783272125 date "2018-01-11" @default.
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- W2783272125 title "Relationships between lewy and tau pathologies in 375 consecutive non‐Alzheimer's olfactory bulbs" @default.
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- W2783272125 doi "https://doi.org/10.1002/mds.27250" @default.
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