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- W2783272135 abstract "Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a multilayer transcription factor network to achieve a dramatic remodeling of the B cell transcriptional landscape. Increased levels of ASCs are often seen in autoimmune diseases and it is believed that altered expression of regulatory transcription factors play a role in this imbalance. The transcription factor interferon regulatory factor 5 (IRF5) is one such candidate as polymorphisms in IRF5 associate with risk of numerous autoimmune diseases and correlate with elevated IRF5 expression. IRF5 genetic risk has been widely replicated in systemic lupus erythematosus (SLE), and loss of Irf5 ameliorates disease in murine lupus models, in part, through the lack of pathogenic autoantibody secretion. It remains unclear, however, whether IRF5 is contributing to autoantibody production through a B cell-intrinsic function. To date, IRF5 function in healthy human B cells has not been characterized. Using human primary naïve B cells, we define a critical intrinsic role for IRF5 in B cell activation, proliferation and plasmablast differentiation. Targeted IRF5 knockdown resulted in significant IgD retention, reduced proliferation, plasmablast differentiation, and IgG secretion. The observed decreases were due to impaired B cell activation and clonal expansion. Distinct from murine studies, we identify and confirm new IRF5 target genes, IRF4, ERK1, and MYC, and pathways that mediate IRF5 B cell-intrinsic function. Together, these results identify IRF5 as an early regulator of human B cell activation and provide the first dataset in human primary B cells to map IRF5 dysfunction in SLE." @default.
- W2783272135 created "2018-01-26" @default.
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- W2783272135 date "2018-01-10" @default.
- W2783272135 modified "2023-10-17" @default.
- W2783272135 title "B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation" @default.
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- W2783272135 doi "https://doi.org/10.3389/fimmu.2017.01938" @default.
- W2783272135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768180" @default.
- W2783272135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29367853" @default.
- W2783272135 hasPublicationYear "2018" @default.
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