FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783274477> ?p ?o ?g. }

• W2783274477 endingPage "e0190841" @default.
• W2783274477 startingPage "e0190841" @default.
• W2783274477 abstract "Long-term alcohol use can result in lasting changes in brain function, ultimately leading to alcohol dependence. These functional alterations arise from dysregulation of complex gene networks, and growing evidence implicates microRNAs as key regulators of these networks. We examined time- and brain region-dependent changes in microRNA expression after chronic intermittent ethanol (CIE) exposure in C57BL/6J mice. Animals were sacrificed at 0, 8, and 120h following the last exposure to four weekly cycles of CIE vapor and we measured microRNA expression in prefrontal cortex (PFC), nucleus accumbens (NAC), and amygdala (AMY). The number of detected (395–419) and differentially expressed (DE, 42–47) microRNAs was similar within each brain region. However, the DE microRNAs were distinct among brain regions and across time within each brain region. DE microRNAs were linked with their DE mRNA targets across each brain region. In all brain regions, the greatest number of DE mRNA targets occurred at the 0 or 8h time points and these changes were associated with microRNAs DE at 0 or 8h. Two separate approaches (discrete temporal association and hierarchical clustering) were combined with pathway analysis to further characterize the temporal relationships between DE microRNAs and their 120h DE targets. We focused on targets dysregulated at 120h as this time point represents a state of protracted withdrawal known to promote an increase in subsequent ethanol consumption. Discrete temporal association analysis identified networks with highly connected genes including ERK1/2 (mouse equivalent Mapk3, Mapk1), Bcl2 (in AMY networks) and Srf (in PFC networks). Similarly, the cluster-based analysis identified hub genes that include Bcl2 (in AMY networks) and Srf in PFC networks, demonstrating robust microRNA-mRNA network alterations in response to CIE exposure. In contrast, datasets utilizing targets from 0 and 8h microRNAs identified NF-kB-centered networks (in NAC and PFC), and Smad3-centered networks (in AMY). These results demonstrate that CIE exposure results in dynamic and complex temporal changes in microRNA-mRNA gene network structure." @default.
• W2783274477 created "2018-01-26" @default.
• W2783274477 creator A5011222626 @default.
• W2783274477 creator A5023439185 @default.
• W2783274477 creator A5048293201 @default.
• W2783274477 creator A5070752030 @default.
• W2783274477 creator A5082855062 @default.
• W2783274477 date "2018-01-09" @default.
• W2783274477 modified "2023-10-17" @default.
• W2783274477 title "Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain" @default.
• W2783274477 cites W1060653271 @default.
• W2783274477 cites W1462212705 @default.
• W2783274477 cites W1487581481 @default.
• W2783274477 cites W1503193875 @default.
• W2783274477 cites W1533671266 @default.
• W2783274477 cites W1840163537 @default.
• W2783274477 cites W1881072801 @default.
• W2783274477 cites W1897269170 @default.
• W2783274477 cites W1919665879 @default.
• W2783274477 cites W1926838596 @default.
• W2783274477 cites W1976944452 @default.
• W2783274477 cites W1987256529 @default.
• W2783274477 cites W1988071883 @default.
• W2783274477 cites W2016149358 @default.
• W2783274477 cites W2026570544 @default.
• W2783274477 cites W2026984303 @default.
• W2783274477 cites W2027981586 @default.
• W2783274477 cites W2040461594 @default.
• W2783274477 cites W2045348002 @default.
• W2783274477 cites W2047998720 @default.
• W2783274477 cites W2052338190 @default.
• W2783274477 cites W2056340982 @default.
• W2783274477 cites W2059073003 @default.
• W2783274477 cites W2059117644 @default.
• W2783274477 cites W2066617812 @default.
• W2783274477 cites W2067381654 @default.
• W2783274477 cites W2068411972 @default.
• W2783274477 cites W2075527287 @default.
• W2783274477 cites W2075690567 @default.
• W2783274477 cites W2076878451 @default.
• W2783274477 cites W2077070485 @default.
• W2783274477 cites W2078665080 @default.
• W2783274477 cites W2081098333 @default.
• W2783274477 cites W2083381199 @default.
• W2783274477 cites W2089592748 @default.
• W2783274477 cites W2091204859 @default.
• W2783274477 cites W2102288730 @default.
• W2783274477 cites W2106809828 @default.
• W2783274477 cites W2108856177 @default.
• W2783274477 cites W2117949279 @default.
• W2783274477 cites W2120270169 @default.
• W2783274477 cites W2134097555 @default.
• W2783274477 cites W2135945534 @default.
• W2783274477 cites W2161053574 @default.
• W2783274477 cites W2170989872 @default.
• W2783274477 cites W2178027752 @default.
• W2783274477 cites W2181707684 @default.
• W2783274477 cites W2203621986 @default.
• W2783274477 cites W2218134682 @default.
• W2783274477 cites W2226740446 @default.
• W2783274477 cites W2339621642 @default.
• W2783274477 cites W2343186061 @default.
• W2783274477 cites W2398660354 @default.
• W2783274477 cites W2416623094 @default.
• W2783274477 cites W2563179195 @default.
• W2783274477 cites W2565520898 @default.
• W2783274477 cites W2595425890 @default.
• W2783274477 cites W2607482562 @default.
• W2783274477 cites W2743674492 @default.
• W2783274477 cites W4243408844 @default.
• W2783274477 cites W819026494 @default.
• W2783274477 doi "https://doi.org/10.1371/journal.pone.0190841" @default.
• W2783274477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5760035" @default.
• W2783274477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315347" @default.
• W2783274477 hasPublicationYear "2018" @default.
• W2783274477 type Work @default.
• W2783274477 sameAs 2783274477 @default.
• W2783274477 citedByCount "28" @default.
• W2783274477 countsByYear W27832744772018 @default.
• W2783274477 countsByYear W27832744772019 @default.
• W2783274477 countsByYear W27832744772020 @default.
• W2783274477 countsByYear W27832744772021 @default.
• W2783274477 countsByYear W27832744772022 @default.
• W2783274477 countsByYear W27832744772023 @default.
• W2783274477 crossrefType "journal-article" @default.
• W2783274477 hasAuthorship W2783274477A5011222626 @default.
• W2783274477 hasAuthorship W2783274477A5023439185 @default.
• W2783274477 hasAuthorship W2783274477A5048293201 @default.
• W2783274477 hasAuthorship W2783274477A5070752030 @default.
• W2783274477 hasAuthorship W2783274477A5082855062 @default.
• W2783274477 hasBestOaLocation W27832744771 @default.
• W2783274477 hasConcept C104317684 @default.
• W2783274477 hasConcept C105580179 @default.
• W2783274477 hasConcept C121332964 @default.
• W2783274477 hasConcept C145059251 @default.
• W2783274477 hasConcept C150194340 @default.
• W2783274477 hasConcept C165864922 @default.
• W2783274477 hasConcept C18431079 @default.

• next