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- W2783275203 abstract "AIM: The aim of the study is to extract a polysaccharide from the fruit of the Solanumbetaceum Cav and to studythe characteristic of the polysaccharide as a binding agent in theformulation of tablets.OBJECTIVE: To isolate polysaccharidefrom Solanum betaceum cav fruit, To evaluate its physicochemical properties of the polysaccharide. To formulate and evaluate paracetamol tablet using above polysaccharide. RESULTS AND DISCUSSION:Physicochemical characterization of isolated mucilage powder:The physicochemicalof Solanum betaceum cav mucilage were observed and the resultswere presented in table and. The identification tests of mucilage gave positive test forcarbohydrate, mucilage in Molisch’s and ruthenium tests respectively and the iodine test gavenegative test for starch, thus polysaccharides is confirmed. The results were presented in table 7.Extracted and purified mucilage was evaluated for viscosityand pH. The pH of the mucilagewas found to be 6.1. Since the pH value of this mucilage is near to neutral, it may be lessirritating on gastrointestinal tract and hence was suitable for uncoated tablets. The flowproperties of mucilage powder weredetermined by Carr’s index, Hausner’s ratio and angle ofrepose was found to be >23, >1.25, and 36⁰ - 40⁰ indicated poor and passable flow properties. CONCLUSION: The market for drug delivery system has come a long way and will continue to grow at animpressive rate.Today’s drug delivery technologies enable the incorporation of drug moleculesinto a new delivery system thus providing numerous therapeutic and commercial advantages.Natural materials readily available,cost effective,eco-friendly, biodegradable and biocompatibledue to their natural origin can be extensively used in the field of drug delivery. In recent year, theinterest is growing to develop multiparticulate drug delivery systemwith the use of naturalpolymer thereby increasing the therapeutic value as well as reducing toxicity. On the basis of thisdissertation work ,polysaccharide isolated from fruit of Solanum betaceum cav shows excellentbinding property with no interaction in itcomparision with existing polymers.In futurethepolymer characteristics can be studied for sustain releaseproperty andit may be used as a novelpolymer in drug delivery system.." @default.
- W2783275203 created "2018-01-26" @default.
- W2783275203 creator A5035768817 @default.
- W2783275203 date "2017-04-01" @default.
- W2783275203 modified "2023-09-27" @default.
- W2783275203 title "Physicochemical Characterisation and Binding Property of Polysaccharide of Solanum Betaceum Cav In Tablet Formulation" @default.
- W2783275203 hasPublicationYear "2017" @default.
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