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- W2783276464 abstract "This chapter describes a large-scale three-dimensional (3D) computer simulation of trabecular remodeling in a human proximal femur in order to understand the mechanism of the Law of Bone Transformation, proposed by Wolff in the nineteenth century. A large-scale voxel finite element model is constructed to simulate the 3D structural changes of individual trabeculae over a cancellous bone. As a simple remodeling model that considers bone cellular activities regulated by the local mechanical environment, the nonuniformity of local stress is assumed to drive the trabecular surface remodeling to seek a uniform stress state (Chap. 8). In the simulation, cell-scale (10 μm) remodeling in response to mechanical stimulation creates complex 3D trabecular structures at the entire bone-scale (10 cm), as observed by Wolff in an actual femur. It is indicated that in a complex mechanical environment of a hierarchical bone structure with a length scale of greater than 104 (from 10 μm to 10 cm), a simple remodeling at the cellular/trabecular levels creates a highly complex and functional trabecular structure, as characterized by bone density and orientation." @default.
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- W2783276464 date "2018-01-01" @default.
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- W2783276464 title "3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff’s Law" @default.
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