FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783282588> ?p ?o ?g. }

• W2783282588 endingPage "512" @default.
• W2783282588 startingPage "509" @default.
• W2783282588 abstract "Background Chronic rhinosinusitis (CRS) may be initiated by innately impaired host defense mechanisms that predispose the upper airways to infection. Recent evidence suggests tethering of submucosal gland mucus strands represents an inciting event within cystic fibrosis (CF) airways, occurring prior to onset of chronic infection. Submucosal gland hypertrophy and defective mucociliary clearance (MCC) are present in actively inflamed sinuses, but mucus strand velocity may also be affected as a secondary event, further contributing to chronic disease. The objective of this study is to assess whether mucus strand velocity is decreased in patients with CRS. Methods Mucosal explants from patients with and without CRS were submerged in Ringer's solution mixed with fluorescent nanospheres. Methacholine was then added, and videos demonstrating strand growth and detachment were generated from a time‐lapse of Z‐stack images using a multiphoton confocal microscope. Dynamic mucus strands were identified and individual velocities quantified with the MTrackJ plug‐in of ImageJ. Results Fifteen patients met criteria for ex vivo analysis of mucus strand velocities (CRS, n = 9 vs controls, n = 6). Mucus strands were recorded (pixels/second) streaming from the submucosal gland openings. Average mucus strand velocities were significantly decreased in patients with CRS (1.53 ± 0.67 vs controls, 4.86 ± 1.68 pixels/second; p < 0.001). Conclusion This study is the first to report evidence of abnormal mucus strand velocity from submucosal glands in diseased sinonasal mucosa. Future pharmacologic studies targeting this critical component of MCC are warranted." @default.
• W2783282588 created "2018-01-26" @default.
• W2783282588 creator A5014429496 @default.
• W2783282588 creator A5027281315 @default.
• W2783282588 creator A5035736153 @default.
• W2783282588 creator A5036733807 @default.
• W2783282588 creator A5040323712 @default.
• W2783282588 creator A5050727273 @default.
• W2783282588 creator A5053048232 @default.
• W2783282588 creator A5053921897 @default.
• W2783282588 creator A5061587101 @default.
• W2783282588 creator A5078359206 @default.
• W2783282588 date "2018-01-10" @default.
• W2783282588 modified "2023-10-12" @default.
• W2783282588 title "Submucosal gland mucus strand velocity is decreased in chronic rhinosinusitis" @default.
• W2783282588 cites W148711126 @default.
• W2783282588 cites W1981369450 @default.
• W2783282588 cites W1983495573 @default.
• W2783282588 cites W1984185512 @default.
• W2783282588 cites W2004978232 @default.
• W2783282588 cites W2026100561 @default.
• W2783282588 cites W2044380511 @default.
• W2783282588 cites W2051463089 @default.
• W2783282588 cites W2086569637 @default.
• W2783282588 cites W2093897486 @default.
• W2783282588 cites W2112530308 @default.
• W2783282588 cites W2121159616 @default.
• W2783282588 cites W2121890764 @default.
• W2783282588 cites W2128270521 @default.
• W2783282588 cites W2131145961 @default.
• W2783282588 cites W2132963900 @default.
• W2783282588 cites W2137075043 @default.
• W2783282588 cites W2171286149 @default.
• W2783282588 cites W2275028388 @default.
• W2783282588 cites W2295678160 @default.
• W2783282588 cites W2320633596 @default.
• W2783282588 cites W2498147069 @default.
• W2783282588 cites W2508533199 @default.
• W2783282588 cites W2732522704 @default.
• W2783282588 cites W2752092283 @default.
• W2783282588 cites W4252523298 @default.
• W2783282588 doi "https://doi.org/10.1002/alr.22065" @default.
• W2783282588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6520985" @default.
• W2783282588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29319936" @default.
• W2783282588 hasPublicationYear "2018" @default.
• W2783282588 type Work @default.
• W2783282588 sameAs 2783282588 @default.
• W2783282588 citedByCount "10" @default.
• W2783282588 countsByYear W27832825882020 @default.
• W2783282588 countsByYear W27832825882021 @default.
• W2783282588 countsByYear W27832825882023 @default.
• W2783282588 crossrefType "journal-article" @default.
• W2783282588 hasAuthorship W2783282588A5014429496 @default.
• W2783282588 hasAuthorship W2783282588A5027281315 @default.
• W2783282588 hasAuthorship W2783282588A5035736153 @default.
• W2783282588 hasAuthorship W2783282588A5036733807 @default.
• W2783282588 hasAuthorship W2783282588A5040323712 @default.
• W2783282588 hasAuthorship W2783282588A5050727273 @default.
• W2783282588 hasAuthorship W2783282588A5053048232 @default.
• W2783282588 hasAuthorship W2783282588A5053921897 @default.
• W2783282588 hasAuthorship W2783282588A5061587101 @default.
• W2783282588 hasAuthorship W2783282588A5078359206 @default.
• W2783282588 hasBestOaLocation W27832825882 @default.
• W2783282588 hasConcept C114682108 @default.
• W2783282588 hasConcept C126322002 @default.
• W2783282588 hasConcept C142724271 @default.
• W2783282588 hasConcept C150903083 @default.
• W2783282588 hasConcept C18903297 @default.
• W2783282588 hasConcept C207001950 @default.
• W2783282588 hasConcept C26291073 @default.
• W2783282588 hasConcept C2776385078 @default.
• W2783282588 hasConcept C2776938444 @default.
• W2783282588 hasConcept C2777312293 @default.
• W2783282588 hasConcept C2777714996 @default.
• W2783282588 hasConcept C3019717275 @default.
• W2783282588 hasConcept C529295009 @default.
• W2783282588 hasConcept C71924100 @default.
• W2783282588 hasConcept C86803240 @default.
• W2783282588 hasConceptScore W2783282588C114682108 @default.
• W2783282588 hasConceptScore W2783282588C126322002 @default.
• W2783282588 hasConceptScore W2783282588C142724271 @default.
• W2783282588 hasConceptScore W2783282588C150903083 @default.
• W2783282588 hasConceptScore W2783282588C18903297 @default.
• W2783282588 hasConceptScore W2783282588C207001950 @default.
• W2783282588 hasConceptScore W2783282588C26291073 @default.
• W2783282588 hasConceptScore W2783282588C2776385078 @default.
• W2783282588 hasConceptScore W2783282588C2776938444 @default.
• W2783282588 hasConceptScore W2783282588C2777312293 @default.
• W2783282588 hasConceptScore W2783282588C2777714996 @default.
• W2783282588 hasConceptScore W2783282588C3019717275 @default.
• W2783282588 hasConceptScore W2783282588C529295009 @default.
• W2783282588 hasConceptScore W2783282588C71924100 @default.
• W2783282588 hasConceptScore W2783282588C86803240 @default.
• W2783282588 hasFunder F4320337338 @default.
• W2783282588 hasFunder F4320337351 @default.
• W2783282588 hasFunder F4320337357 @default.
• W2783282588 hasFunder F4320337376 @default.
• W2783282588 hasIssue "4" @default.

• next