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• W2783283011 abstract "Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE2 in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A2, which has been previously shown to reduce PGE2 synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE2 production, similar to that observed for GK115." @default.
• W2783283011 created "2018-01-26" @default.
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• W2783283011 date "2018-01-13" @default.
• W2783283011 modified "2023-09-26" @default.
• W2783283011 title "Small Peptides Able to Suppress Prostaglandin E2 Generation in Renal Mesangial Cells" @default.
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• W2783283011 doi "https://doi.org/10.3390/molecules23010158" @default.
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