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• W2783287956 abstract "// Yingying Meng 1, 2, * , Jing Zhang 1, 2, * , Cong Yuan 1, 2 , Fenglin Zhang 1, 2 , Qin Fu 1, 2 , Han Su 1, 2 , Xiaotong Zhu 1, 2 , Lina Wang 1, 2 , Ping Gao 1, 2 , Gang Shu 1, 2 , Qingyan Jiang 1, 2 and Songbo Wang 1, 2 1 Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, P. R. China 2 National Engineering Research Center for Breeding Swine Industry and UBT Lipid Suite Functional Fatty Acids Research Center, South China Agricultural University, Guangzhou 510642, P. R. China * These authors are co-first authors Correspondence to: Songbo Wang, email: songbowang@scau.edu.cn Keywords: oleic acid (OA); mammary gland development; CD36-[Ca 2+ ]i; PI3K/Akt; peripubertal mice Received: October 21, 2017      Accepted: December 05, 2017      Published: January 12, 2018 ABSTRACT This study aimed to investigate the effects of oleic acid (OA), a monounsaturated fatty acid, on HC11 mammary epithelial cells proliferation and peripubertal mammary gland development and explore the underlying mechanisms. HC11 cells and C57BL/6J mice were treated with OA. HC11 proliferation, peripubertal mammary gland development, and the involvement of CD36 and PI3K/Akt were assessed. In vitro , 100 μM OA significantly promoted HC11 proliferation by increasing Cyclin D1/3 and PCNA expression and decreasing p21 expression. Meanwhile, OA enhanced CD36 expression, elevated [Ca 2+ ] i and activated PI3K/Akt signaling pathway. However, knockdown of CD36, chelation of [Ca 2+ ] i or inhibition of PI3K eliminated the OA-induced promotion of HC11 proliferation and change in proliferative markers expression. In vivo , peripubertal exposure to diet containing 2% OA stimulated mammary duct development, with increased terminal duct end (TDE) and ductal branch. Moreover, dietary OA increased the serum levels of IGF-1 and E2, enhanced the expression of CD36 and Cyclin D1, and activated PI3K/Akt pathway in mammary glands. In conclusion, OA stimulated HC11 cells proliferation and mammary gland development in peripubertal mice, which was associated with activation of CD36-[Ca 2+ ] i and PI3K/Akt signaling pathway. These data provided new insights into the stimulation of mammary gland development by dietary oleic acid." @default.
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• W2783287956 date "2018-01-12" @default.
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• W2783287956 title "Oleic acid stimulates HC11 mammary epithelial cells proliferation and mammary gland development in peripubertal mice through activation of CD36-Ca2+ and PI3K/Akt signaling pathway" @default.
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• W2783287956 doi "https://doi.org/10.18632/oncotarget.24204" @default.
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